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Methyclothiazide (diuretic, antihypertensive agent)

Methyclothiazide is a thiazide diuretic. Diuretics help the body release or excrete extra water stored in the cells and tissues. This reduces swelling and blood volume.


What is Methyclothiazide used for?

  • Edema
  • Hypertension
  • Cardiovascular disease

How should I take Methyclothiazide?

Read the directions on the packaging for complete information. Check the label and expiration date.

For oral dosage forms, swallow it whole without chewing, crushing, or dissolving it in liquid.

How do I store Methyclothiazide?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Methyclothiazide?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A= No risk
  • B= No risk in some studies
  • C= There may be some risk
  • D= Positive evidence of risk
  • X= Contraindicated
  • N= Unknown

Side effects

What side effects can occur from Methyclothiazide?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Headache
  • Cramping
  • Nausea
  • Vomiting
  • Diarrhea, constipation
  • Abdominal pain
  • Decreased appetite
  • Orthostatic hypotension (low blood pressure upon standing)
  • Pancreatitis
  • Jaundice
  • Sialadenitis
  • Anemia
  • Fever
  • Skin rash
  • Photosensitivity
  • High blood sugar (hyperglycemia)
  • Electrolyte imbalance
  • Muscle spasm
  • Blurred vision
  • Sugar in the urine (glycosuria)

Seek medical attention immediately if you experience any of the following potentially fatal effects:

  • Stevens-Johnson syndrome
  • Respiratory distress
  • Anaphylaxis

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Methyclothiazide?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Other diuretics
  • Other antihypertensive agents
  • Anticholinergics
  • Antidiabetic agents
  • Bile acid sequestrants
  • Fexinidazole
  • Lithium
  • Steroids
  • Insulin
  • Norepinephrine, epiniephrine
  • Tubocurarine
  • Barbiturates
  • Narcotics
  • Topiramate

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Methyclothiazide?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Avoid consuming alcohol while taking this drug. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Methyclothiazide?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Allergy to thiazides or sulfonamides (“sulfa” drugs)
  • Dehydration
  • Photosensitive skin
  • Diabetes
  • Adrenal insufficiency
  • Gout
  • Hepatic impairment
  • Hypercalcemia (high calcium)
  • Hypercholesterolemia, dyslipidemia (high cholesterol)
  • Hypokalemia (low potassium)
  • Kidney impairment
  • Parathyroid disease
  • Systemic lupus erythematosus (SLE)


The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?


Take 2.5 to 5 mg orally once a day, either as monotherapy or with other antihypertensive drugs.


Take 2.5 to 5 mg orally once a day. Up to 10 mg a day.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Methyclothiazide available?

Methyclothiazide is available in the following dosage forms and strengths:

  • Tablet 5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


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Hello Health Group does not provide medical advice, diagnosis or treatment.


Methyclothiazide https://www.mims.com/philippines/drug/info/methyclothiazide?mtype=generic Accessed July 25, 2021

Methyclothiazide (Oral Route) https://www.mayoclinic.org/drugs-supplements/methyclothiazide-oral-route/description/drg-20071783 Accessed July 25, 2021

Methyclothiazide https://pubchem.ncbi.nlm.nih.gov/compound/Methyclothiazide Accessed July 25, 2021

Methyclothiazide https://www.uofmhealth.org/health-library/d00643a1 Accessed July 25, 2021

Methyclothiazide. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed July 25, 2021. http://online.lexi.com

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Written by Stephanie Nera, RPh, PharmD Updated Jul 27, 2021