backup og meta
Health Screening
Ask Doctor

Neo-Synephrine Nasal Spray

Written by Stephanie Nera, RPh, PharmD · Pharmacology

Updated Jul 28, 2021

Neo-Synephrine nasal spray is a product that contains phenylephrine hydrochloride. Phenylephrine works by reducing swelling of the mucus membranes which makes it easier to breathe.



What is Neo-Synephrine used for?

Temporarily relieving symptoms due to:

  • Common cold
  • Hay fever
  • Allergies
  • Sinus congestion and pressure

How should I take Neo-Synephrine?

Read the directions on the packaging for complete information. Check the label and expiration date.

Steps for using this product:

  1. Blow your nose to remove excess mucus.
  2. Wash your hands thoroughly with mild soap and water.
  3. Gently shake the bottle and remove the cap without touching the nozzle.
  4. Tilt your head forward and press a finger against the side of one nostril.
  5. Insert the nozzle into the open nostril.
  6. Maintain the bottle in an upright position while aiming for the back of the nose.
  7. Squeeze the bottle 2 to 3 times while breathing normally.
  8. Repeat these steps in the other nostril.
  9. Wash your hands after using this product.

How do I store Neo-Synephrine?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Neo-Synephrine?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to use phenylephrine as a nasal spray. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A= No risk
  • B= No risk in some studies
  • C= There may be some risk
  • D= Positive evidence of risk
  • X= Contraindicated
  • N= Unknown

Side Effects

What side effects can occur from Neo-Synephrine?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Worsening or recurrence of nasal congestion (with long-term use)
  • Burning
  • Stinging
  • Sneezing
  • Increased nasal discharge

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Neo-Synephrine?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Does food or alcohol interact with Neo-Synephrine?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Neo-Synephrine?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Heart disease
  • Hypertension
  • Thyroid disease
  • Diabetes
  • Enlarged prostate


The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Spray 2 to 3 times in each nostril, not exceeding every 4 hours (6 times a day).

What is the dose for a child?

Children 12 years and older: Same as the adult dose, using the 0.5% (regular) or 1.0% (extra-strength) preparation.

Children 6 years and older: Same as the adult dose, using the 0.25% (mild) preparation.

How is Neo-Synephrine available?

Neo-Synephrine is available in the following dosage forms and strengths:

  • Extra-strength nasal spray 1.0%
  • Regular nasal spray 0.5%
  • Mild nasal spray 0.25%

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Hello Health Group does not provide medical advice, diagnosis or treatment.

Written by

Stephanie Nera, RPh, PharmD


Updated Jul 28, 2021

ad iconadvertisement

Was this article helpful?

ad iconadvertisement
ad iconadvertisement