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Xyzal (levocetirizine diHCl, antihistamine)

Xyzal  is the brand name of the generic drug levocetirizine dihydrochloride. It is available without a prescription or over-the-counter (OTC).

Levocetirizine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itchiness, and hives. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

Uses

What is Xyzal used for?

Xyzal manages symptoms such as sneezing, watery eyes, itchiness, and rashes due to:

  • Allergic rhinitis
  • Urticaria

How should I take Xyzal?

Read the directions on the packaging for complete information. Check the label and expiration date.

For oral dosage forms, swallow it whole without chewing, crushing, or dissolving it in liquid.

For oral solutions, use a medical-grade measuring cup or dropper not a household spoon.

How do I store Xyzal?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Xyzal?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A= No risk
  • B= No risk in some studies
  • C= There may be some risk
  • D= Positive evidence of risk
  • X= Contraindicated
  • N= Unknown

Side Effects

What side effects can occur from Xyzal?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Headache
  • Drowsiness
  • Sleep disorders
  • Dry mouth
  • Fatigue
  • Diarrhea
  • Constipation

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Xyzal?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. 

Drugs with known interactions:

  • Other antihistamines
  • Theophylline
  • Ritonavir
  • CNS depressants
  • Alcohol-containing preparations

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Xyzal?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Do not consume alcohol while taking this drug. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Xyzal?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Hypersensitivity to piperazine derivatives or other antihistamines
  • Urinary retention
  • Kidney impairment
  • Liver impairment
  • Glucose, galactose, or fructose intolerance

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Take 5 mg once a day.

Dose adjustment for patients with renal impairment, based on creatinine clearance:

  • 50-80 mL/min: 5 mg once a day.
  • 30-49 mL/min: 5 mg once every 2 days.
  • <30 mL/min: 5 mg once every 3 days.
  • <10 mL/min: Do not take this medication.

What is the dose for a child?

Ages 6 years and above: Give 5 mg once a day (equivalent to 1 tablet, 10 mL of solution, or 20 drops)

Ages 2 to 6 years old: Give 2.5 mg (equivalent to 2.5 mL of solution or 5 drops) two times a day.

How is Xyzal available?

Xyzal is available in the following dosage forms and strengths:

  • Film-coated tablet 5 mg
  • Oral drops 5 mg/mL
  • Oral solution 500 mcg/mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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Disclaimer

Hello Health Group does not provide medical advice, diagnosis or treatment.

Xyzal https://www.mims.com/philippines/drug/info/xyzal Accessed July 25, 2021

Xyzal https://products.sanofi.us/xyzal/xyzal.pdf Accessed July 25, 2021

Xyzal® (levocetirizine) https://www.ucb.com/clinical-studies/Clinical-studies-index/Xyzal-levocetirizine Accessed July 25, 2021

Xyzal https://www.xyzal.com/ Accessed July 25, 2021

Levocetirizine. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed July 25, 2021. http://online.lexi.com

Current Version

07/27/2021

Written by Stephanie Nera, RPh, PharmD

Updated by: Stephanie Nera, RPh, PharmD


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