The maximum glucose-lowering effect of a dose of Toujeo may take five days to fully manifest and the first Toujeo dose may be insufficient to cover metabolic needs in the first 24 hours of use. To minimize risks associated with insufficient insulin uptake when initiating Toujeo, monitor glucose daily, titrate Toujeo per instructions, and adjust co-administered glucose-lowering therapies per standard of care.
Type 2 Diabetes
The recommended starting dose of Toujeo in insulin naïve patients with type 2 diabetes is 0.2 units per kilogram of body weight once daily. The dosage of other anti-diabetic drugs may need to be adjusted when starting Toujeo® to minimize the risk of hypoglycemia.
Starting Dose in Patients with either Type 1 or Type 2 Diabetes Already on Insulin Therapy
To minimize the risk of hypoglycemia when changing patients from a once-daily long-acting or intermediate-acting insulin product to Toujeo, the starting dose of Toujeo can be the same as the once-daily long-acting dose. For patients controlled on Lantus® (insulin glargine, 100 units/mL) expect that a higher daily dose of Toujeo will be needed to maintain the same level of glycemic control.
To minimize the risk of hypoglycemia when changing patients from twice-daily NPH insulin to once-daily Toujeo, the recommended starting Toujeo dose is 80% of the total daily NPH dosage.
To minimize the risk of hyperglycemia when changing patients to Toujeo, monitor glucose frequently in the first weeks of therapy titrate the dose of Toujeo per instructions and the dose of other glucose-lowering therapies per standard of care.
What is the dose for a child?
Children 6 years and older, the dose should be individualized.
For children under 6 years, Toujeo is not recommended. It may not be safe to administer it to a child. Talk to your child’s pediatrician for more information.
How is Toujeo available?
Toujeo is available in the following dosage forms and strengths:
- SoloStar Pen with 450 units of insulin per pen
- Max SoloStar Pen with 900 units of insulin per pen
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.
What should I do if I miss a dose?
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
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