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Trimetazidine (antianginal agent)

Know the basics|Know the precautions & warnings|Know the side effects|Know the interactions|Understand the dosage

Trimetazidine is an anti-anginal drug which is useful for treating stable angina pectoris.

Trimetazidine

Know the basics

What is trimetazidine used for?

  • Chronic stable angina
  • Ischemic heart disease
  • Heart failure

How should I take trimetazidine?

Read the directions on the packaging for complete information. Check the label and expiration date.

The oral tablets should be swallowed whole without crushing, chewing, or dissolving in liquid. Take it with meals.

How do I store trimetazidine?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using trimetazidine?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe to take trimetazidine during pregnancy or breast-feeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Know the side effects

What are the side effects of trimetazidine?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Dizziness
  • Headache
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Rash, itching, hives
  • Weakness

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with trimetazidine?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Does food or alcohol interact with trimetazidine?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with trimetazidine?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Understand the dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

As conventional tab: 40-60 mg daily in divided doses.

What is the dose for a child?

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

How is trimetazidine available?

Trimetazidine is available in the following dosage forms and strengths:

  • Tablet: 20 mg
  • Modified-release tablet: 35 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Trimetazidine https://www.mims.com/philippines/drug/info/trimetazidine?mtype=generic Accessed June 11, 2021

Trimetazidine https://www.ema.europa.eu/en/medicines/human/referrals/trimetazidine Accessed June 11, 2021

Trimetazidine and Other Metabolic Modifiers https://www.ecrjournal.com/articles/trimetazidine-and-other-metabolic-modifiers Accessed July 1, 2021

Trimetazidine in Heart Failure https://www.frontiersin.org/articles/10.3389/fphar.2020.569132/full Accessed July 1, 2021

Trimetazidine. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed July 1, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jul 01
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