- Severe allergic reactions: rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue
- Blood in urine
- Changes in hearing
- Dark, bloody stools
- Dark urine
- Fast breathing
- Lack of energy
- Lower back pain
- Red, swollen, or blistered skin
- Ringing in the ears
- Sore throat
- Tingling of the arms or legs
- Unusual bleeding or bruising
- Vision changes
- Yellowing of the skin or eyes
However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.
Know the interactions
What drugs may interact with acetazolamide?
This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.
To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.
Drugs with known interactions:
- Arsenic Trioxide
If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.
Does food or alcohol interact with acetazolamide?
This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Avoid drinking alcohol while taking this drug. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with acetazolamide?
This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:
- Type 2 diabetes mellitus
- Emphysema or other chronic lung disease
- Low blood levels of potassium or sodium
- Kidney disease or stones
- Liver disease
- Underactive adrenal gland (Addison’s disease)
Understand the dosage
The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.
What is the dose for an adult?
- 250 to 375 mg oral or intravenous once a day.
When continued acetazolamide therapy for edema is desired, it is recommended that every second or third dose be skipped to allow the kidney to recover.
Acute Mountain Sickness
- Oral tablet: 125 to 250 mg orally every 6 to 12 hours.
- SR capsule: 500 mg orally every 12 to 24 hours.
The maximum recommended dose is 1 gram/day.
For rapid ascent, higher doses are beneficial for preventing acute mountain sickness beginning 24 to 48 hours before ascent and continuing for 48 hours while at high altitude.
- tablet or intravenous injection: 250 mg 1 to 4 times a day.
- SR capsule: 500 mg once or twice a day.
- 250 to 500 mg intravenous, may repeat in 2 to 4 hours to a maximum of I gram/day.
- 8 to 30 mg/kg/day in 1 to 4 divided doses. Do not exceed 1 gram per day.
If this patient is already taking other anticonvulsants, the recommended starting dosage is 250 mg once a day. If acetazolamide is used alone, most patients with good renal function respond to daily doses ranging from 375 to 1000 mg. The optimum dosage for this patient with renal dysfunction is not known, and will depend on this patient’s clinical response and tolerance.
What is the dose for a child?
Glaucoma (over 1 year old)
- Oral: 8 to 30 mg/kg/day or 300 to 900 mg/m²/day divided every 8 hours.
- intravenous: 20 to 40 mg/kg/day divided every 6 hours. Maximum dose: 1 gram/day.
Edema (over 1 year old)
- Oral or intravenous: 5 mg/kg or 150 mg/mÂ² once a day.
Epilepsy (over 1 year old)
- Oral: 8 to 30 mg/kg/day in 1 to 4 divided doses. Maximum dose is 1 gram/day.
Hydrocephalus (under 1 year old)
- Oral or intravenous: 20 to 100 mg/kg/day divided every 6 to 8 hours. Maximum dose is 2 grams/day.
How is Acetazolamide available?
Acetazolamide is available in the following dosage forms and strengths:
- Capsule, extended-release: 500mg
- Tablet, Oral: 125mg, 250mg
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.
What should I do if I miss a dose?
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.