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Toplexil (oxomemazine + guaifenesin)

Written by Stephanie Nera, RPh, PharmD · Pharmacology

Updated Jul 19, 2021

Toplexil is the brand name of a preparation that contains oxomemazine and guaifenesin. Oxomemazine is an antihistamine while guaifenesin is an expectorant.

Currently, this brand is not available in the Philippines. This information is only for educational purposes.



What is Toplexil used for?

Toplexil is a preparation that contains the antihistamine oxomemazine and the expectorant guaifenesin. It treats cold symptoms such as runny nose, sneezing, and cough accompanied by phlegm (“plema’).

Oxomemazine is currently not approved by the FDA for use in the US or Philippines.

How should I take Toplexil?

Read the directions on the packaging for complete information. Check the label and expiration date.

For each dose, use a medical-grade measuring cup not a household spoon.

How do I store Toplexil?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Toplexil?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.
  • Is it safe during pregnancy or breastfeeding?

    Excessive doses of oxomemazine can be harmful to the fetus. The manufacturer recommends avoiding use of oxomemazine during the first trimester of pregnancy.

    It is also present in breast milk and can induce sleepiness in a nursing baby. Breastfeeding generally not recommended while taking this drug.

    Side Effects

    What side effects can occur from Toplexil?

    Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

    • Skin rash
    • Allergic reaction
    • Photosensitivity
    • Dry mouth
    • Low blood pressure
    • Palpitations
    • Dizziness
    • Drowsiness
    • Changes in mood
    • Trouble concentrating
    • Memory impairment
    • Hallucination
    • Urinary retention
    • Tremor
    • Visual disturbances

    However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.


    What drugs may interact with Toplexil?

    This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

    To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. 

    Drugs with known interactions:

    • Aclidinium
    • Azelastine
    • Benzylpenicilloyl polylysine
    • Bromperidol
    • Cimetropium
    • Eluxadoline
    • Glycopyrronium
    • Ipratropium
    • Levosulpiride
    • Orphenadrine
    • Oxatomide
    • Paraldehyde
    • Pitolisant
    • Potassium chloride
    • Potassium citrate
    • Pramlintide
    • Revefenacin
    • Secretin
    • Thalidomide
    • Tiotropium
    • Umeclidinium
    • Other antihistamines
    • Alcohol-containing preparations
    • Sedative-hypnotics
    • COVID-19 vaccines

    If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

    Does food or alcohol interact with Toplexil?

    This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Do not consume alcohol while taking this drug. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

    What health conditions may interact with Toplexil?

    This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

    • CNS depression
    • Constipation
    • Obstructive bowel disease
    • Photosensitive skin
    • Severe heart disease
    • Liver impairment
    • Epilepsy
    • Prostate disorders
    • Kidney impairment
    • Asthma
    • GERD


    The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

    What is the dose for an adult?

    Adults and children weighing more than 40 kg (i.e. age 12):

    The recommended dose is 10 ml per dose, 4 times a day.

    What is the dose for a child?

    Children: the daily dosage depends upon the weight of your child:

    • 10 to 20 kg  (ages 2 to 6 years ): The recommended dose is 5 ml per dose, 2 to 3 times a day.
    • 20 to 30 kg (ages 6 to 10 years): The recommended dose is 10 ml per dose, 2 to 3 times a day.
    • 30 to 40 kg (ages 10 to 12 years): The recommended dose is 10 ml per dose, 3 to 4 times a day.

    How is Toplexil available?

    This drug not available in the Philippines.

    What should I do in case of an emergency or overdose?

    In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

    What should I do if I miss a dose?

    If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


    Hello Health Group does not provide medical advice, diagnosis or treatment.

    Written by

    Stephanie Nera, RPh, PharmD


    Updated Jul 19, 2021

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