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Selbex (Teprenone)

Selbex is the brand name of the drug teprenone. Teprenone is used to treat gastritis and peptic ulcer. It works by increasing bicarbonate levels in gastric mucus and also helps heal gastric lesions, such as ulcers. Some studies have shown that it can provide some protection against NSAID-induced peptic ulcer disease (PUD).



What is Selbex used for?

Selbex is commonly used for improvement of gastric mucosal lesions (erosion, hemorrhage, redness and edema) in acute gastritis, acute exacerbation stage of chronic gastritis, and used in gastric ulcers.

How should I take Selbex?

For orally taken form, you should:

  • Take Selbex by mouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using Selbex.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store Selbex?

Selbex is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of teprenone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Selbex?

Before using Selbex, tell your doctor if you are/have:

  • An allergic reaction to Selbex or any of the inactive ingredients.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Used any other health conditions, drugs that have a risk of interaction with Selbex.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Selbex?

As taking others medicines, taking Selbex can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of side effects are:

  • A slight increase in liver enzymes
  • Constipation
  • Bloating
  • Diarrhea
  • Dry mouth
  • Nausea
  • Abdominal pain
  • Headache
  • Skin eruption
  • Itchiness
  • Redness & warm feeling in the eyelids
  • Increase in total serum cholesterol levels

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Selbex?

Selbex may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Selbex?

Selbex may interact with food or alcohol by altering the way the drug works or increasing the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Selbex?

Selbex may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


What is the dose for an adult?

The recommended dose is three capsules (50 mg) taken three times a day. The dosage may be adjusted depending on the patient’s age and symptoms.

What is the dose for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Selbex available?

Selbex is available in the following dosage forms and strengths:

  • Capsule, oral 50 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


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Hello Health Group does not provide medical advice, diagnosis or treatment.


Selbex https://www.mims.com/philippines/drug/info/selbex Accessed May 28, 2021

Selbex https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=36574 Accessed May 28, 2021

Teprenone https://pubchem.ncbi.nlm.nih.gov/compound/Teprenone Accessed May 28, 2021

Teprenone https://www.mims.com/philippines/drug/info/teprenone?mtype=generic Accessed May 28, 2021

Efficacy of Teprenone for Prevention of NSAID-Induced Gastrointestinal Injury: A Systematic Review and Meta-Analysis https://www.frontiersin.org/articles/10.3389/fmed.2021.647494/full Accessed May 28, 2021

Teprenone for the prevention of low-dose aspirin-induced gastric mucosal injury in Helicobacter pylori-negative patients https://www.tandfonline.com/doi/abs/10.1080/00365521.2019.1672781?journalCode=igas20 Accessed May 28, 2021

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Written by Stephanie Nera, RPh, PharmD Updated May 28, 2021