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Hordenine (N,N-dimethyltyramine supplement)

Written by Stephanie Nera, RPh, PharmD · Pharmacology

Updated May 30


Uses of hordenine

Hordenine is a phenylethylamine alkaloid found in barley (Hordeum vulgare) that is used to brew beer. It is similar in chemical structure to stimulants found in bitter orange. It can also be found in algae, cacti, and some grass species.

People take hordenine by mouth for improving athletic performance and weight loss. In some studies, the chemical has shown antibiotic properties and is used as a biomarker for determining the amount of beer a person has consumed.

asians drinking beer

How does it work?

The uses of hordenine are still being studied, however, some research shows that it might stimulate the central nervous system, increase heart rate, blood pressure, and breathing rate. These effects seem to be short-lived and require relatively high doses.

How do I store hordenine?

Store at room temperature, away from moisture and direct sunlight. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of this drug that may have different storage needs. Therefore, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush it down the toilet or pour them into a drain unless instructed to do so. Additionally, do not use it if expired. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using hordenine?

Before using this drug, tell your doctor or pharmacist if you:

  • Are pregnant or breastfeeding
  • Are taking other medications
  • Have ever had an allergic reaction to any medication
  • Have any other co-morbidities or conditions

The regulations for an herbal supplement are less strict than the regulations for a drug. More studies are needed to determine its safety. The benefits of taking this herbal supplement must outweigh the risks before use. Consult with your doctor or pharmacist for more information.

How safe is hordenine?

The indicated use and safety of hordenine as a dietary supplement has not been established. As of April 2019, hordenine is on the USFDA’s Dietary Supplement Ingredient Advisory List, making it potentially unsafe.

Side effects

What kind of side effects may I have from hordenine?

In some cases, hordenine might have a stimulating effect with side effects such as rapid heart rate and high blood pressure. However, not everyone experiences these side effects. There may be some side effects not listed above. Therefore, if you have any concerns about side effects, please consult a doctor or pharmacist.


What drugs may interact with hordenine?

This drug may interact with your current medications or medical conditions. Therefore, it is important to consult with your pharmacist or doctor before using it.

Does food or alcohol interact with hordenine?

There is no available data on the food interactions with hordenine. Hordenine may have an additive or synergistic effect with other stimulants and alcohol (e.g. beer). Discuss with your doctor or pharmacist regarding any potential food or alcohol interactions before using this drug.

Health conditions that may interact with hordenine

This drug may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for medical advice. ALWAYS consult doctor or pharmacist before using this drug.

What is the dose?

The dose for hordenine may be different for every patient. The dose that you take depends on your age, health, and several other conditions. Herbal supplement are not always safe. Therefore, please discuss with your herbalist or doctor for your appropriate dosage.

What form does hordenine come in?

Hordenine may be available in the following dosage forms, although not yet approved by the FDA:

  • Encapsulated hordenine supplements
  • Hordenine HCl powder
  • A naturally occurring compound in certain food/herbs

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Hello Health Group does not provide medical advice, diagnosis or treatment.

Written by

Stephanie Nera, RPh, PharmD


Updated May 30

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