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The Side Effects of Taking Pain Relievers

The Side Effects of Taking Pain Relievers

Be honest: how often do you take pain relievers, like non-steroidal anti-inflammatory drugs (NSAIDs)? If you feel like you’re becoming too reliant on these medicines, read on. In this article, we’ll talk about the NSAID side effects long-term use.

What are NSAIDs?

NSAIDs, which stand for non-steroidal anti-inflammatory drugs, are widely used medication that help relieve pain, bring down fever, and reduce inflammation.

Many brands of NSAIDs are sold over the counter, meaning you don’t need a doctor’s prescription to purchase them. Examples of OTC NSAIDs include:

In most cases, people only use these painkillers for pressing complaints, like backache, headache, dental pain, menstrual cramps, and other muscle pains.

However, there are instances when they become reliant on them; that is, they take a pill at the first symptom of pain. But is this practice safe? Are there side effects to long-term NSAID use?

NSAID side effects long-term use

Common NSAID side effects long-term use

While these medicines provide relief from inflammation, fever, and pain, experts agree they come with side effects.

These side effects include gastrointestinal symptoms like indigestion, stomach pain, nausea, and diarrhea. NSAIDs may also lead to dizziness, salt and fluid retention, and drowsiness.

Alarmingly, the long-term use of NSAID may also result in more severe side effects, such as:


Reports indicate that all NSAIDs, in doses that relieve pain and inflammation, can increase the blood pressure in people with normal BP and those with existing hypertensive condition.

Additionally, these painkillers may reduce the effects of BP-lowering drugs except for calcium-channel blockers.

Increased risk of heart attack and stroke

Health authorities also warn the public that all NSAIDs, save for aspirin, increase the risk of stroke and heart attack.

They also mentioned that the increased risk might occur within the first weeks of using the painkillers. Moreover, the longer you use it and the higher the dose you take, the greater your risk is, too.

Harm to the kidneys

One of the most concerning side effects of long-term NSAID use is kidney damage. According to experts, long-term and heavy use of these pain relievers can cause chronic kidney diseases even in people with normal kidney function.

For this reason, they advise patients with kidney problems to refrain from using NSAIDs unless they discussed it first with their doctor.

Rebound headaches

As ironic as it sounds, NSAIDs can also cause rebound headaches.

Rebound headaches or medication overuse headaches occur due to excessive intake of pain medicines.

In one report, it was mentioned that people with migraines who take drugs like naproxen and ibuprofen for more than 15 days a month are at risk of rebound headaches.

Ulcers and bleeding

Finally, the long-term use of NSAID could lead to peptic ulcers and bleeding.

In one study, the researchers mentioned that chronic users of the drug have visible damage to the intestine and increased bleeding risk.

Another report mentioned that about 1% of participants who used NSAIDs for 3 to 6 months experienced stomach ulcers, perforation, and bleeding. The percentage increased in participants who used the medicines for about one year.

How to safely use NSAIDs

The best way to safely take an NSAID is to consult your doctor first, especially if you’re worried about the side effects of its long-term use.

If you want to take it without a prescription or a doctor’s advice, always take the lowest possible dose at the shortest period.

For fever, don’t take NSAIDs for more than 3 days. For pain, please don’t take it for more than 10 days. The only time you’ll break these rules is when the doctor gives you specific instructions on how long to take the medicines.

Alternative to NSAIDs

Since there are side effects to long term NSAID use, consider the following alternatives first before reaching for a painkiller:

  • Heat, either from a warm compress or hot shower.
  • Cold compress
  • Yoga or other stretching exercises

Finally, for pain relief, consider applying creams, oils, or gels first. On many occasions, they work just as fine.

Learn more about Drugs and Supplements here.

Hello Health Group does not provide medical advice, diagnosis or treatment.


NSAIDs and acetaminophen: Effects on blood pressure and hypertension
Accessed May 26, 2021

FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes
Accessed May 26, 2021

Pain Medicines (Analgesics)
Accessed May 26, 2021

Stopping the vicious cycle of rebound headaches
Accessed May 26, 2021

Study Shows Long-term Use Of NSAIDs Causes Severe Intestinal Damage
Accessed May 26, 2021

Therapeutic Class Overview Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Accessed May 26, 2021

Pain relief: Taking NSAIDs safely
Accessed May 26, 2021

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Accessed May 26, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jul 07