Now, it is established that aspirin alone can help with migraine pain, but what about coke? Coke, cola, or other soft drinks contain caffeine (and plenty of sugar). Because a can of coke and a few aspirin tablets are easily accessible and relatively cheap, it sounds like a win-win situation. Is aspirin and coke for migraine safe? The combination is not as harmless as it sounds.
Why it is NOT recommended
Truthfully, there are mixed findings and opinions regarding the use of caffeine to treat headaches. Some studies have shown that caffeine can improve pain relief when combined with NSAIDs (e.g. paracetamol, ibuprofen, aspirin). On the other hand, research and anecdotal evidence show that it can actually trigger headaches.
While coke and aspirin are generally safe when taken separately, aspirin and coke for migraine is not a great idea.
Firstly, aspirin is an acidic drug (it is chemically similar to vinegar). Typically, aspirin is enteric-coated to prevent release in the stomach. Secondly, coke and carbonated drinks are also acidic. Taking both of these highly acidic substances together is not recommended, especially for those with GERD, PUD, or hyperacidity.
This is why most medications should be taken with water only. Additionally, too much intake of caffeine and sugar can lead to symptoms of dependency. Withdrawal and rebound are two reasons why some people feel worse headaches when they skip their morning coffee or try to cut down on caffeine.