For migraines, aspirin may be used to alleviate pain. High doses of 900 mg to 1300 mg at the onset of a migraine attack have been shown to relieve pain and prevent its return for several hours.
Now, it is established that aspirin alone can help with migraine pain, but what about coke? Coke, cola, or other soft drinks contain caffeine (and plenty of sugar). Because a can of coke and a few aspirin tablets are easily accessible and relatively cheap, it sounds like a win-win situation. Is aspirin and coke for migraine safe? The combination is not as harmless as it sounds.
Why it is NOT recommended
Truthfully, there are mixed findings and opinions regarding the use of caffeine to treat headaches. Some studies have shown that caffeine can improve pain relief when combined with NSAIDs (e.g. paracetamol, ibuprofen, aspirin). On the other hand, research and anecdotal evidence show that it can actually trigger headaches.