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Aspegic (lysine acetylsalicylate)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Aspegic is the brand name of lysine acetylsalicylate. Lysine acetylsalicylate is similar to aspirin (acetylsalicylic acid, ASA). Aspirin has pain reliving and antiplatelet properties. It does this by blocking the cyclooxygenase (COX-1 and COX-2) enzymes. Aspirin is also a nonsteroidal anti-inflammatory drug (NSAID).

aspegic

Uses

What is Aspegic used for?

This drug is indicated to treat pain of various origins, including:

  • Arthritis
  • Muscle soreness
  • Headache
  • Migraine

How should I take Aspegic?

This product is available in different dosage forms. Oral dosage forms should be taken by mouth. Intravenous (IV) dosage forms need to be administered by a licensed health professional (e.g. doctor, nurse).

How do I store Aspegic?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of aspirin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour it into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Aspegic?

  • Using caution in patients with liver diseases and kidney, bronchial asthma, erosive and ulcerative lesions, and bleeding from the digestive tract in history, with increased bleeding or while holding anticoagulant therapy, decompensated congestive heart failure.
  • The use of acetylsalicylic acid as anti-inflammatory drugs in a daily dose of 5-8 g is limited due to the high probability of adverse effects from the gastrointestinal tract.
  • Before surgery, to reduce bleeding during surgery and postoperative period, patients should stop taking salicylates for 5-7 days.
  • During prolonged therapy, it is necessary to conduct a general analysis of blood and study of occult blood.

Is it safe during pregnancy or breastfeeding?

Pregnancy

Aspirin is contraindicated during the third trimester of pregnancy. Additionally, it should be avoided during the first trimester of pregnancy. Talk to your doctor about what medications you can use while prenant.

Breastfeeding

Aspirin is excreted in breast milk, which can increase the risk of bleeding in infants. Avoid using this drug while lactating and breastfeeding. Talk to your doctor about alternatives.

Side effects

What side effects can occur from Aspegic?

If you notice any of the following side effects, call your doctor for more information.

  • Gastrointestinal pain, ulceration, or bleeding
  • CNS disturbances with long-term use (e.g. dizziness, headache, visual disturbances, tinnitus)
  • Anemia (e.g. fatigue, pallor)
  • Bleeding disorders
  • Kidney problems
  • Allergic reactions
  • Reyes syndrome (mainly in children)

Interactions

What drugs may interact with Aspegic?

Aspegic may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Drugs that have known interactions with Aspegic include:

  • Antacids containing magnesium and/or aluminum hydroxide
  • Calcium channel blockers
  • Blood thinners, anticoagulants
  • Diuretics (e.g. spironolactone, furosemide)
  • NSAIDs
  • Probenecid, sulfinpyrazone, benzbromarone
  • Alendronate sodium
  • Griseofulvin
  • Ginkgo biloba
  • Dipyridamole
  • Barbiturates
  • Digoxin
  • Caffeine
  • Metoprolol

Does food or alcohol interact with Aspegic?

Avoid consuming alcohol while taking this medication. Doing so may increase the risk of gastrointestinal ulceration and bleeding. In addition, this medication is best taken with food or meals to prevent gastric irritation.

What health conditions may interact with Aspegic?

Aspegic may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Antipyretic and analgesic

500-1000 mg per day (up to 3 g) were divided into 3 doses.

Myocardial infarction

40-325 mg 1 time a day (usually 160 mg).

Thrombosis or occlusion of the aortic shunt

325 mg every 7 h after intranasal gastric tube set, and then through the mouth to 325 mg 3 times a day.

What is the dose for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Aspegic available?

Aspegic is available in the following dosage forms and strengths:

  • Injectable; Injection: 1000 mg
  • Injectable; Injection: 500 mg
  • Powder for Solution; Oral: 100 mg
  • Powder for Solution; Oral: 1000 mg
  • Powder for Solution; Oral: 250 mg
  • Powder for Solution; Oral: 500 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Aspegic powder https://www.lagaay.com/Catalogus/Product%20information/032820/Aspegic%20powder%20Leaflet.pdf Accessed May 30, 2021

Aspegic IV https://www.lagaay.com/Catalogus/Product%20information/041270/Aspegic%20iv%20Leaflet.pdf Accessed May 30, 2021

Aspegic https://pubchem.ncbi.nlm.nih.gov/compound/Aspegic#section=Deprecated-CAS Accessed May 30, 2021

Impact of Intravenous Lysine Acetylsalicylate Versus Oral Aspirin on Prasugrel-Inhibited Platelets https://www.ahajournals.org/doi/full/10.1161/circinterventions.114.002281 Accessed May 30, 2021

Aspirin https://www.ahajournals.org/doi/10.1161/01.CIR.101.10.1206 Accessed May 30, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated May 30
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