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Know the basics|Know the precautions & warnings|Know the side effects|Know the interactions|Understand the dosage

Know the basics

What is lorazepam used for?

Lorazepam is used to treat anxiety. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. This drug works by enhancing the effects of a certain natural chemical in the body (GABA).

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your healthcare professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

If directed by your doctor, this drug may also be used to reduce the symptoms of alcohol withdrawal, to prevent nausea and vomiting due to chemotherapy, and for trouble sleeping (insomnia).

How should I take lorazepam?

Take loprazepam by mouth with or without food as directed by your doctor. This drug is also available as an IV solution for injection. The dosage is based on your medical condition, age, and response to treatment.

If directed by your doctor, use loprazepam regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Loprazepam may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses (more than 1-4 weeks) or if you have a history of alcoholism, drug abuse, or personality disorder. Withdrawal symptoms (such as seizures, trouble sleeping, mental/mood changes, nausea, vomiting, diarrhea, loss of appetite, stomach pain, hallucinations, numbness/tingling of arms and legs,muscle pain, fast heartbeat, short-term memory loss, very high fever, and increased reactions to noise/touch/light) may occur if you suddenly stop using loprazepam. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Report any withdrawal reactions immediately.

Along with its benefits, loprazepam may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take loprazepam exactly as prescribed to lessen the risk of addiction.

Do not suddenly stop using this drug without consulting your doctor. Some conditions may become worse when this drug is abruptly stopped. Your dose may need to be gradually decreased.

When loprazepam is used for a long time, it may not work as well. Talk with your doctor if loprazepam stops working well.

Tell your doctor if your condition persists or worsens.

How do I store lorazepam?

Loprazepam is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store loprazepam in the bathroom or the freezer. There may be different brands of loprazepam that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush loprazepam down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using lorazepam?

Before taking lorazepam,

  • Tell your doctor and pharmacist if you are allergic to lorazepam, alprazolam (Xanax), chlordiazepoxide (Librium, Librax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), estazolam (prosom), flurazepam (Dalmane), oxazepam (Serax), prazepam (Centrax), temazepam (Restoril), triazolam (Halcion), any other loprazepams, or any of the ingredients in lorazepam tablets or concentrate. Ask your doctor or pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription loprazepams, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; digoxin (Lanoxin); levodopa (Larodopa, Sinemet); loprazepams for depression, seizures, pain, Parkinson’s disease, asthma, colds, or allergies; muscle relaxants; oral contraceptives; probenecid (Benemid); rifampin (Rifadin); sedatives; sleeping pills; theophylline (Theo-Dur); tranquilizers; and valproic acid (Depakene).Your doctor may need to change the doses of your loprazepams or monitor you carefully for side effects.
  • Tell your doctor if you have or have ever had glaucoma; seizures; or lung, heart, or liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lorazepam, call your doctor immediately.
  • Talk to your doctor about the risks and benefits of taking loprazepam if you are 65 years of age or older. Older adults should take lower doses of lorazepam because higher doses may not be more effective and are more likely to cause serious side effects.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lorazepam.
  • You should know that loprazepam may make you drowsy. Do not drive a car or operate machinery until you know how loprazepam affects you.
  • Talk to your doctor about the safe use of alcohol during your treatment with lorazepam. Alcohol can make the side effects of loprazepam worse.
  • Tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of loprazepam.

Is it safe to take lorazepam during pregnancy or breast-feeding?

Please always consult with your doctor to weigh the potential benefits and risks before taking loprazepam. Loprazepam is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

This drug is not recommended for use during pregnancy. There is evidence that suggests that lorazepam can increase the risk of fetal harm and withdrawal symptoms, especially during the first trimester.

Know the side effects

What are the side effects of lorazepam?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • Confusion, depressed mood, thoughts of suicide or hurting yourself;
  • Hyperactivity, agitation, hostility;
  • Hallucinations;
  • Feeling light-headed, fainting.

Less serious side effects may include:

  • Drowsiness, dizziness, tiredness;
  • Blurred vision;
  • Sleep problems (insomnia);
  • Muscle weakness, lack of balance or coordination;
  • Amnesia or forgetfulness, trouble concentrating;
  • Nausea, vomiting, constipation;
  • Appetite changes;
  • Skin rash.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with lorazepam?

Loprazepam may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

  • A barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
  • An MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
  • Medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
  • Narcotic loprazepams such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (oxycontin), propoxyphene (Darvon, Darvocet);
  • Antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

Does food or alcohol interact with lorazepam?

Loprazepam may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Do not take this drug with alcohol or grapefruit juice. Grapefruit and food products that contain it can increase the amount of lorazepam in the body and potentially worsen side effects. Alcohol is extremely dangerous when taken with any benzodiazepine. Taking them together can cause slowed breathing, excessive sedation, coma, and even death. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with lorazepam?

Loprazepam may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Glaucoma, acute narrow-angle or
  • Lung disease, severe or
  • Sleep apnea (temporary stopping of breathing during sleep)—This medicine should not be used in patients with these conditions.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Lung disease, mild to moderate—Use with caution. May make this condition worse.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using loprazepam.

What is the dose of loprazepam for an adult?


For status epilepticus:

Adult: 4 mg IV as a single dose, may be repeated once after 10-15 minutes if seizure continues or recurs.

Elderly: Reduce to lower doses (half the usual adult dose or less).

Prior to surgery:

Adult: 0.05 mg/kg given 30-45 minutes before surgery via IV or 60-90 minutes before surgery via IM.

Elderly: Reduce to lower doses (half the usual adult dose or less).

For acute anxiety:

Adult: IV/IM: 0.025-0.03 mg/kg, may be repeated 6 hourly if necessary. Give IV inj at a rate of not more than 2 mg/minute.

Elderly: Reduce to lower doses (half the usual adult dose or less).


For anxiety:

Adult: 1-4 mg daily in divided doses for 2-4 weeks.

Elderly: Reduce to lower doses (half the usual adult dose or less).

Prior to surgery:

Adult: 2-3 mg given the night before the operation followed by 2-4 mg 1-2 hours before the procedure.

Elderly: Reduce to lower doses (half the usual adult dose or less).

Insomnia associated with anxiety:

Adult: 1-2 mg at bedtime.

Elderly: Reduce to lower doses (half the usual adult dose or less).

What is the dose of loprazepam for a child?


For status epilepticus:

Child: 2 mg as a single dose.


Prior to surgery:

Child: 5-13 years 0.5-2.5 mg at 0.05 mg/kg to the nearest 0.5 mg based on weight, not less than 1 hour before operation.

How is loprazepam available?

Loprazepam is available in the following dosage forms and strengths:

  • Tablet, Oral: 0.5 mg, 1 mg, 2 mg.
  • Solution for intravenous or intramuscular injection.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of loprazepam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Lorazepam. https://www.drugs.com/lorazepam.html. Accessed June, 27, 2016.
Lorazepam (Injection Route). http://www.mayoclinic.org/drugs-supplements/lorazepam-injection-route/description/drg-20072326. Accessed June, 27, 2016.
lorazepam – injection, Ativan. http://www.medicinenet.com/lorazepam-injection/article.htm. Accessed June, 27, 2016.

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Written by Ruby Fernandez on May 02, 2020