Are you sure you want to log out?
Please tell us what was incorrect.
Please tell us what was missing.
We’re unable to offer personal health advice, diagnosis, or treatment, but we welcome your feedback! Just type it in the box below.
This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines.
This medication is not recommended for use in children younger than 2 years or in children going through surgery.
Unwrap and insert one suppository rectally as directed by your doctor, usually 2 times a day. Remain lying down for a few minutes after using this medication, and avoid having a bowel movement for an hour or longer so the drug will be absorbed. The suppository is for rectal use only.
The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often than directed.
Tell your doctor if your condition persists or worsens.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
If you take prochlorperazine long-term, you may need frequent medical tests.
If you need to have an x-ray or CT scan of your spinal column using a dye that is injected into a vein, you may need to temporarily stop taking prochlorperazine. Be sure the doctor knows ahead of time that you are taking this medication.
Do not stop using prochlorperazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using prochlorperazine.
Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Some medical conditions may interact with prochlorperazine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Pregnancy and breastfeeding: There is not enough information about the safety of using pancreatin during pregnancy and breast-feeding. It is best to avoid use unless you have been diagnosed with pancreas problems that make use of Prochlorperazine essential.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using prochlorperazine and call your doctor at once if you have a serious side effect such as:
Less serious side effects may include:
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
Prochlorperazine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Some medicines may interact with Prochlorperazine. Tell your health care provider if you are taking any other medicines, especially any of the following:
Many prescription and nonprescription medicines (eg, used for allergies, blood clotting problems, cancer, infections, inflammation, aches and pains, heart problems, high blood pressure, high cholesterol, irregular heartbeat, mental or mood problems, nausea or vomiting, Parkinson disease, seizures, stomach or bowel problems, overactive bladder), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John’s wort) may interact with prochlorperazine. Ask your doctor if you are unsure if any of your medicines may interact with prochlorperazine.
Prochlorperazine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.]
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Prochlorperazine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Prochlorperazine.
Usual Adult Dose for Nausea/Vomiting
Severe nausea and vomiting:
Tablet: 5 to 10 mg 3 to 4 times a day.
Capsule: 15 mg on arising or 10 mg capsule every 12 hours. Daily oral doses above 40 mg should be used only in resistant cases.
Rectal: 25 mg twice a day.
IM: 5 to 10 mg. If necessary, repeat every 3 to 4 hours. Total IM dosage should not exceed 40 mg/day.
IV: 2 1/2 to 10 mg by slow IV injection or infusion at a rate not to exceed 5 mg/min.
A single dose of the drug should not exceed 10 mg. Total IV dosage should not exceed 40 mg/day.
Adult surgery (for severe nausea and vomiting):
IM: 5 to 10 mg injection 1 to 2 hours before induction of anesthesia (repeat once in 30 minutes, if necessary), or to control acute symptoms during and after surgery (repeat once if necessary).
IV: 5 to 10 mg as a slow IV injection or infusion 15 to 30 minutes before induction of anesthesia, or to control acute symptoms during or after surgery. Repeat once if necessary. A single dose of the drug should not exceed 10 mg. The rate of administration should not exceed 5 mg/minute.
Usual Adult Dose for Anxiety
Tablet: 5 mg 3 to 4 times a day.
Capsule: 15 mg on arising or 10 mg every 12 hours.
Do not administer in doses of more than 20 mg/day or for longer than 12 weeks.
Usual Adult Dose for Psychosis
Mild psychotic disorders:
5 to 10 mg orally 3 to 4 times a day.
Moderate to severe psychotic disorders:
Oral: 10 mg orally 3 to 4 times a day. Increase dosage every 2 to 3 days until symptoms are controlled or side effects become bothersome. Some patients respond satisfactorily on 50 to 75 mg/day. In more severe disturbances, optimum dosage is usually 100 to 150 mg/day.
IM: For immediate control of severely disturbed adults, inject an initial dose of 10 to 20 mg deeply into the upper outer quadrant of the buttock. Many patients respond shortly after the first injection. If necessary, repeat the initial dose every 2 to 4 hours (or, in resistant cases, every hour) to gain control of the patient. More than 3 to 4 doses are seldom necessary. After control is achieved, switch patient to an oral form of the drug at the same dosage level or higher. If, in rare cases, parenteral therapy is needed for a prolonged period, give 10 to 20 mg every 4 to 6 hours.
Children seem more prone to develop extrapyramidal reactions, even on moderate doses. Therefore, use lowest effective dosage.
Prochlorperazine is available in the following dosage forms and strengths:
Tablets: 5mg; 10 mg
Capsule: 10 mg; 15 mg
Vials: 2 mL (5 mg/mL); 10 mL (5 mg/mL)
Suppositories: 2.5 mg; 5 mg; 25 mg
Syrup: 5 mg/5 mL
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
Symptoms of overdose may include:
If you miss a dose of Prochlorperazine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Prochlorperazine. https://www.drugs.com/mtm/prochlorperazine.html. Accessed July 26, 2016.
Prochlorperazine. http://www.webmd.com/drugs/2/drug-4824/prochlorperazine-rectal/details. Accessed July 26, 2016.