It is not known if Entresto is excreted in breastmilk. However, animal studies of valsartan and sacubitril showed that these drugs could pass into breastmilk. Because of this, it is not recommended for lactating mothers to breastfeed unless approved by a doctor or OB-GYN.
Side effects
What side effects can occur from Entresto?
Get emergency medical help if you have signs of an allergic reaction to Entresto: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Also call your doctor at once if you have:
- A light-headed feeling, like you might pass out
- Extreme tiredness
- High potassium – slow heart rate, weak pulse, muscle weakness, tingly feeling
- Kidney problems – little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath
Common side effects may include:
Not everyone experiences these side effects. Additionally, there may be other side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.
Interactions
What drugs may interact with Entresto?
Entresto may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Products that may interact with this drug are:
- Aliskiren
- Lithium
- Any other heart or blood pressure medicines
- A diuretic or “water pill”
- Medicine or mineral supplements that contain potassium
- NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others
Does food or alcohol interact with Entresto?
Entresto may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Entresto?
Entresto may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
Dosage
The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.
What is the dose for an adult?
Usual Adult Dose for Congestive Heart Failure:
Initial dose: take 100 mg tablet orally twice a day. Double the dose at 2-4 weeks to the target dose of 200 mg twice a day as tolerated by the patient.
If the patient is not currently taking an ACE inhibitor or ARB: start at 50 mg twice a day and slow dose titration (doubling every 3 to 4 weeks).
For patients with systolic BP >100-110 mmHg, moderate to severe renal impairment, or moderate hepatic impairment (Child-Pugh B): starting dose is 50 mg taken twice a day.
What is the dose for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is Entresto available?
Entresto is available in the following dosage forms and strengths:
- Tablet, film-coated: 50 mg, 100 mg, 200 mg (each 50 mg contains sacubitril 24.3 mg + valsartan 25.7 mg)
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room. Signs and symptoms of an overdose or toxicity include:
- Dizziness
- Fainting
- Low urine output
- Headache
- Diarrhea
- Fatigue
- Muscle weakness
- Loss of consciousness
What should I do if I miss a dose?
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Comments
Share your thoughts
Be the first to let Hello Doctor know your thoughts!
Join Us or Log In to join the discussion