What drugs may interact with Dormicum)?
This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.
To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.
Drugs with known interactions:
- St. John’s wort
If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.
Does food or alcohol interact with Dormicum?
Do not drink alcohol for at least 24 hours after taking midazolam. This medication can increase the effects of alcohol, which could be dangerous.
Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking midazolam.
What health conditions may interact with Dormicum?
This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:
- Acute alcohol intoxication
- Open-angle glaucoma
- Asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems
- Kidney or liver disease
- Congestive heart failure
- Conditions or chronic pain that require opioid treatment
The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.
What is the dose for an adult?
- For short-term management of insomnia: 7.5 to 15 mg, ideally at bedtime.
- The dose may need adjustment for elderly patients.
For sedation for dental and minor surgical procedures:
Initial dose: 2-2.5 mg at a rate of 2 mg/min 5-10 min before procedure, with increments of 0.5-1 mg at intervals of at least 2 min. Total dose: 2.5-7.5 mg.
For sedation in critical care:
Loading dose: 0.03-0.3 mg/kg, may be given in increments of 1-2.5 mg at 2 min between each dose.
Maintenance: 0.02-0.2 mg/kg/hr. Patients w/ hypothermia, hypovolaemia or vasoconstriction: Reduce or omit loading dose, and reduce maintenance dose.
Total dose: 150-250 mcg/kg in premedicated patients and 300-350 mcg/kg for those without premedication. Sedation in combined anaesth: 30-100 mcg/kg by inj or 30-100 mcg/kg/hr by infusion.
Premedication in surgery :
70-100 mcg/kg 20-60 min before surgery by deep IM injection or 1-2 mg, 5-30 min before surgery by IV injection, repeat dose if necessary.
What is the dose for a child?
Ages 6 months to 16 years old: 0.25-1 mg/kg, as a single dose 20-30 minutes before the procedure. Maximum dose of 20 mg.
Treatment of seizures:
Ages 3-12 months: 2.5 mg; 1-5 years: 5 mg; 5-10 years: 7.5 mg; 10-18 years: 10 mg. Doses are to be given as a single dose.
Preoperative sedation (IM):
Age 1-15 years: 50-150 mcg/kg. Maximum dose of 10 mg.
*Note: IM route should not be used routinely.
Premedication in surgery (IM):
Age 1-15 years: 80-200 mcg/kg given 15-30 mins before surgery by deep IM injection.
Sedation for dental and surgical procedures (IV):
Age 6 months to 5 years: 500-100 mcg/kg, maximum dose of 6 mg.
Age 6-12 years: 25-50 mcg/kg, maximum dose of 10 mg.
Initial doses are given over 2-3 minutes with an additional interval of 2-5 minutes.
Sedation in critical care (IV):
Age 0-32 weeks: 60 mcg/kg/hr via continuous IV infusion, reduce the dose after 24 hours to 30 mcg/kg/hr. The maximum duration of treatment is 4 days.
Age 32 weeks to 6 months: 60 mcg/kg/hr. The maximum duration of treatment is 4 days for neonates.
Age 6 months to 12 years:
Loading dose: 50-200 mcg/kg given via slow injection over 3 minutes or more.
Maintenance dose: 30-120 mcg/kg/hr given as continuous infusion.
Induction of anesthesia (IV):
Age over 7 years: 150 mcg/kg by slow injection.
How is Dormicum available?
Dormicum is available in the following dosage forms and strengths:
- Tablet 7.5mg
- Tablet 15mg
- Solution for injection (IV/IM) 5mg/mL in 3 mL ampule
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.
What should I do if I miss a dose?
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.