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Tyrothricin (topical antibacterial agent)

Tyrothricin is an antibiotic peptide complex produced and extracted from the bacteria Brevibacillus parabrevis (now Aneurinibacillus migulanus). It is effective against gram-positive bacteria and may be combined with other active ingredients like benzocaine.

tyrothricin

Uses

What is Tyrothricin used for?

  • Mouth and throat infections
  • Preventing infections before dental surgeries
  • Skin infections

How should I take Tyrothricin?

Appropriately apply the medication based on its dosage form. For lozenges, take the medication by mouth and allow it to dissolve slowly without chewing or swallowing it.

For the topical route, apply a thin layer of the prepared solution onto the affected area. Do not apply the medication into the nasal cavity or closed body cavities.

How do I store Tyrothricin?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tyrothricin?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breast-feeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side effects

What side effects can occur from Tyrothricin?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Allergic reaction
  • Liver impairment
  • Kidney impairment
  • Loss of smell
  • Stevens-Johnson syndrome (SJS)

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tyrothricin?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Does food or alcohol interact with Tyrothricin?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tyrothricin?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

For the local treatment of oropharyngeal infections: take 4-10 mg per day in the form of a lozenge.

For skin infections (as a 1/1000 diluted solution): apply as directed by your physician.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Tyrothricin available?

Tyrothricin is available in the following dosage forms and strengths:

  • Lozenge
  • Eardrop
  • Cream

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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Disclaimer

Hello Health Group does not provide medical advice, diagnosis or treatment.

Tyrothricin https://www.mims.com/philippines/drug/info/tyrothricin?mtype=generic Accessed June 29, 2021

TYROTHRICIN https://drugs.ncats.io/drug/877376V2XW Accessed June 29, 2021

Tyrothricin https://www.britannica.com/topic/tyrothricin Accessed June 29, 2021

Drug – Tyrothricin https://data.cochrane.org/concepts/r4hp13lwhm71 Accessed June 29, 2021

Tyrothricin. Martindale: The Complete Drug Reference. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 29, 2021. http://online.lexi.com

Current Version

06/29/2021

Written by Stephanie Nera, RPh, PharmD

Updated by: Stephanie Nera, RPh, PharmD


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