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Fugerel (flutamide, antiandrogenic agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Fugerel is the brand name of the drug flutamide. Flutamide is an anti-androgenic agent that helps control the level of androgen (“male” hormone) in the body.

Fugerel

Uses

What is Fugerel used for?

  • Advanced or metastatic prostate cancer
  • Hyperandrogenism (e.g. polycystic ovarian syndrome)
  • Hirsutism

How should I take Fugerel?

Flutamide is usually taken every 8 hours. Drink plenty of liquids while you are taking flutamide. Your doctor may recommend a special diet to help prevent diarrhea.

You should not stop using flutamide suddenly. Stopping suddenly may make your condition worse.

How do I store Fugerel?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Fugerel?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Generally, women should not take flutamide because of potential toxicity. Avoid pregnancy while taking this drug. If you get pregnant, stop taking it and talk to your doctor.

This medication is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A= No risk
  • B= No risk in some studies
  • C= There may be some risk
  • D= Positive evidence of risk
  • X= Contraindicated
  • N= Unknown

Side effects

What side effects can occur from Fugerel?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Breast swelling or tenderness
  • Hot flashes
  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Decreased libido (sex drive)
  • Impotence

Seek medical attention right away if you experience any of the following:

  • Anaphylactic reactions
  • Lethargy
  • Flu-like symptoms
  • Dark urine
  • Clay-colored stools
  • Jaundice (yellowing of the skin or eyes)
  • Rectal hemorrhage

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Fugerel?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Blood thinners

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Fugerel?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Fugerel?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Liver disease
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Hemoglobin M disease

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

The recommended dosage is 1 tablet, 3 times a day at 8-hour intervals preferably before gonadorelin analog treatment for a total daily dose of 750 mg.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Fugerel available?

Fugerel is available in the following dosage forms and strengths:

  • Tablets: 250 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Fugerel https://www.mims.com/philippines/drug/info/fugerel Accessed July 2, 2021

Flutamide (Oral Route) https://www.mayoclinic.org/drugs-supplements/flutamide-oral-route/description/drg-20072536 Accessed July 2, 2021

Flutamide https://pubchem.ncbi.nlm.nih.gov/compound/Flutamide Accessed July 2, 2021

Flutamide https://www.ncbi.nlm.nih.gov/books/NBK482215/ Accessed July 2, 2021

Flutamide. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed July 2, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jul 02
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