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Gonadorelin (gonadotropin-releasing hormone agonist)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Gonadorelin is the synthetic version of gonadotropin-releasing hormone (GnRH). GnRH is responsible for the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

gonadorelin

Uses

What is gonadorelin used for?

  • Primary hypothalamic amenorrhea
  • Gonadotrope stimulation test

How should I take gonadorelin?

This drug is available as an injectable solution. It should be administered by a licensed healthcare professional.

How do I store gonadorelin?

This product is best stored at controlled room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Gonadorelin?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side effects

What side effects can occur from gonadorelin?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Injection site reactions
  • Superficial thrombophlebitis
  • Nausea
  • Abdominal pain
  • Anaphylactic shock
  • Antibody development
  • Hypermenorrhea
  • Ovarian hyperstimulation syndrome

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with gonadorelin?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Does food or alcohol interact with gonadorelin?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with gonadorelin?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Pituitary adenoma

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

For diagnosis of hypothalamic-pituitary-gonadal dysfunction

Administer 100 mcg via IV or SQ injection. It should be given in the early follicular stage of the menstrual cycle (day 1-7).

For primary hypothalamic amenorrhea

Administer using intermittent pulse pump via IV or SQ injection, providing 5-20 mcg over 1 minute. Repeat every 90 minutes for up to 6 months or until conception occurs.

What is the dose for a child?

For diagnosis of hypothalamic-pituitary-gonadal dysfunction

Children >1 year: 2.5 mcg/kg as a single dose. Maximum of 100 mcg per dose.

How is gonadorelin available?

Gonadorelin is available in the following dosage forms:

  • Solution for injection 50 mcg/mL **not for human use

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Gonadorelin https://www.mims.com/philippines/drug/info/gonadorelin?mtype=generic Accessed June 28, 2021

Gonadorelin (Intravenous Route, Injection Route) https://www.mayoclinic.org/drugs-supplements/gonadorelin-intravenous-route-injection-route/description/drg-20067426 Accessed June 28, 2021

Gonadorelin https://pubchem.ncbi.nlm.nih.gov/compound/Gonadorelin Accessed June 28, 2021

Gonadorelin (Intravenous Route, Injection Route) https://www.mayoclinic.org/drugs-supplements/gonadorelin-intravenous-route-injection-route/proper-use/drg-20067426?p=1 Accessed June 28, 2021

Gonadorelin. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 28, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 28
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