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Agaricus Mushroom (Agaricus blazei Murill)

Agaricus mushroom (Agaricus blazei) is a fungus that is native to Brazil and cultivated in other countries such as Japan and China, mainly as ingredients for herbal supplements and extracts.

https://wp.hellodoctor.com.ph/healthy-eating/healthy-eating-tips/mushrooms-reduce-cancer-risk/

Uses

What is Agaricus mushroom used for?

Agaricus mushroom has not been approved by the FDA for any specific treatment, whether alone or in combination with other medications, however, the touted medicinal properties of Agaricus mushroom include:

  • Cancer treatment and prevention
  • Treatment of inflammatory conditions
  • Treatment of allergies
  • Complimentary treatment in diabetes mellitus
  • Antioxidant
  • Immunity boosting

How does it work?

While the exact mechanism of action of Agaricus mushroom has not been established, research has shown that it is rich in β-glucans. β-Glucans are structural sugars that are commonly found in the cell walls of fungi, like the Agaricus mushroom. β-Glucans have antitumor, anti-infective, and anti-inflammatory properties which are mediated by the body’s immune cells.

Precautions & warnings

What should I know before using Agaricus mushroom?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

How safe is Agaricus mushroom?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side effects

What kind of side effects may I have from Agaricus mushroom?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Hypoglycemia in some people with diabetes
  • Liver damage
  • Itching
  • Rashes
  • Nausea
  • Diarrhea

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Agaricus mushroom?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Antidiabetics
    • Glimepiride
    • Glyburide
    • Insulin
    • Pioglitazone
    • Rosiglitazone
    • Chlorpropamide
    • Glipizide
    • Tolbutamide

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Agaricus mushroom?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Agaricus mushroom?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Diabetes
  • Liver damage
  • Allergies to mushrooms

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

For diabetes:

The recommended dose is 500 mg of Agaricus mushroom extract three times daily.

As a dietary supplement:

Take 500 mg two to three times per day with water.

The dose for this supplement may vary from person to person. Consult with your doctor or pharmacist before taking this medication to treat different conditions.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

What form does Agaricus mushroom come in?

This herbal supplement may be available in the following dosage forms:

  • Capsules 200mg, 350mg, 500mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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Sources

Masumax https://www.mims.com/philippines/drug/info/masumax Accessed July 15, 2021

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249742/ Accessed July 15, 2021

Antioxidant properties of Agaricus blazei, Agrocybe cylindracea, and Boletus edulis https://www.sciencedirect.com/science/article/abs/pii/S0023643806002805 Accessed July 15, 2021

Agaricus https://www.mskcc.org/cancer-care/integrative-medicine/herbs/agaricus Accessed July 15, 2021

Gastrointestinal Irritant Mushrooms. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed July 15, 2021. http://online.lexi.com

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Written by Stephanie Nera, RPh, PharmD Updated Jul 16, 2021