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Uses|Precautions & warnings|Side effects|Interactions|Dosage


Note: Spersallerg® has been recalled from the global market since 2014. The information provided here is purely for educational purposes.

What is Spersallerg® (antazoline + tetryzoline) used for?

Spersallerg® is used to provide temporary relief of the signs and symptoms of allergic conjunctivitis including conjunctival hyperemia, chemosis and
itching in adults and children above 2 years of age.

How should I take Spersallerg® (antazoline + tetryzoline)?

To take this drug, you should:

  • Wash your hands with soap and warm water. Dry them with a clean towel.
  • If you are putting in your own eye drops, lie down or use a mirror. It may be helpful to ask someone to check that you are getting the eye drops in your eye.
  • Look up to the ceiling with both eyes.
  • While tilting your head back, pull the lower lid of your eye down with one hand.
  • Hold the eye drops bottle or tube in your other hand (rest part of your hand on your forehead if necessary to keep it steady).
  • Place one eye drop or a small amount of ointment inside your lower lid. The tip of the medicine bottle or tube should not touch your eye.
  • Blink and dab away the excess eye drop fluid with a tissue.

How do I store Spersallerg® (antazoline + tetryzoline)?

Spersallerg® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Spersallerg ® in the bathroom or the freezer. There may be different brands of Spersallerg ® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Spersallerg® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Spersallerg® (antazoline + tetryzoline)?

Before using this drug, you should notice that:

  • As the possibility of adverse effects on the corneal permeability and the danger of disruption of the corneal epithelium with prolonged or repeated usage of benzalkonium chloride preserved ophthalmological preparations cannot be excluded, regular ophthalmological examination is required.
  • Caution should be exercised in the use of benzalkonium chloride preserved topical medication over an extended period in patients with theextensive ocular surface disease.
  • Soft contact lenses should not be worn during the instillation of Spersallerg ® eye drops. They can be reinserted after an interval of at least 5 minutes.
  • Safety in pregnancy and lactation has not been established.
  • Rebound congestion may follow continued use.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Spersallerg® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Spersallerg®.

Side effects

What side effects can occur from Spersallerg® (antazoline + tetryzoline)?

When using this drug, some side effects can occur, including:

  • Transient irritation
  • Systemic reactions (such as headache, drowsiness, and tachycardia)
  • Systemic reactions of antimuscarinic effects (including blurred vision)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Spersallerg® (antazoline + tetryzoline)?

Spersallerg ® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Spersallerg ® (antazoline/ tetrazoline)?

Spersallerg® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Spersallerg® (antazoline + tetryzoline)?

Spersallerg® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially, tell your doctor if you have:

  • Increased intraocular pressure
  • Hypertension
  • Cardiac irregularities
  • Hyperthyroidism
  • Diabetes mellitus


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Spersallerg®.

What is the dose of Spersallerg® (antazoline + tetryzoline) for an adult?

The recommended dose is 1 drop, 3 or 4 times daily, into the lower eyelid.

What is the dose of Spersallerg® (antazoline + tetryzoline) for a child?

Children 2 – 12 years: The recommended dose is 1 drop daily or twice daily.

How is Spersallerg® (antazoline + tetryzoline) available?

Spersallerg® is available in the following dosage forms and strengths:

  • Plastic dropper bottle of 10 ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Spersallerg®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Recall of Spersallerg Eye Drops. https://www.info.gov.hk/gia/general/201408/08/P201408080966.htm. Accessed July 6, 2020

Spersallerg. https://www.mims.com/philippines/drug/info/spersallerg. Accessed July 6, 2020

Spersallerg Composition and Pharmaceutical Form. https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005SPE01E.pdf. Accessed July 6, 2020

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Medically reviewed by Stephanie Nicole Nera, RPh, PharmD
Written by Stephanie Nicole Nera, RPh, PharmD
Updated Jul 31, 2020