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Pyrantel pamoate (anthelmintic, dewormer)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Uses

Uses of pyrantel pamoate

Pyrantel pamoate is a medicinal product known as an antihelminth or dewormer. It is commonly used to prevent worms from growing or multiplying in your body, such as pinworm, roundworm, and hookworm.

Pyrantel pamoate may also be used for other purposes; ask your doctor for more information.

How should I take pyrantel pamoate?

For orally taken form, you should:

  • Take the dose by mouth or as directed by your doctor.
  • Read the label carefully before using pyrantel pamoate.
  • Consult your doctor for any information on the label that you do not clearly understand.

Proper storage conditions

Store at room temperature, away from moisture and direct sunlight. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of this drug that may have different storage needs. Therefore, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush it down the toilet or pour them into a drain unless instructed to do so. Additionally, do not use it if expired. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using pyrantel pamoate?

Before using this drug, tell your doctor if you:
  • Are pregnant or breastfeeding
  • Are taking other medications
  • Have ever had an allergic reaction to any medication
  • Have any allergies to any ingredient in the preparation

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using pyrantel pamoate during pregnancy or while breastfeeding. Therefore, always consult with your doctor to weigh the potential benefits and risks before taking this medication. Pyrantel pamoate is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from pyrantel pamoate?

As with other medications, this drug may have side effects. However, most of side effects are uncommon and typically resolve after you stop taking the drug. In addition, inform your doctor if you experience any uncomfortable side effects. Potential side effects while using this drug include:
  • Nausea
  • Vomiting
  • Abdominal cramps
  • Diarrhea
  • Decreased appetite (anorexia)
  • Headache
  • Drowsiness
  • Dizziness
  • Insomnia
  • Rashes

Not everyone experiences these side effects. Additionally, there may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with pyrantel pamoate?

Pyrantel is known to interact antagonistically with piperazine. These two drugs should not be taken together. However, if necessary, the doses of each may need to be increased. Discuss with your doctor and pharmacist regarding any drug interactions.

Does food or alcohol interact with pyrantel pamoate?

There are no notable food interactions with pyrantel. Discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with pyrantel pamoate?

Pyrantel may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Do not take this drug if you have any of the following conditions:

  • Liver disease (e.g. hepatitis, fatty liver)
  • Anemia
  • Malnutrition

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this drug

What is the dose for an adult?

Single or mixed infections due to susceptible worms

Take 10 mg per kg as a single dose.

Trichinosis

Take 10 mg per kg each day for 5 days.

Necatoriasis

Take 10 mg per kg each day for 3-4 days or 20 mg per kg each day for 2 days.

Enterobiasis

Take 10 mg per kg repeated once after 2-4 wk. Max dose: 1 g per dose.

Ascariasis

Take 5 mg per kg as a single dose. Max: 1 g per dose.

For mass treatment programs: 2.5 mg per kg as a single dose given 3-4 times a year

What is the dose for a child?

As a tablet

Ages: ≥15 years 500 mg, 10-14 years 375 mg, 5-9 years 250 mg, 2-<5 years 125 mg. Preferably, doses should be given preferably 4 times a year or once every 3 months.

As a suspension

Ages: >15 years 4 teaspoons (20 mL), 10-14 years 3 teaspoons (15 mL), 5-9 years 2 teaspoons (10 mL), <5 yr 1 teaspoons (5 mL).

How is pyrantel pamoate available?

Pyrantel is available in the following dosage forms and strengths:

  • Suspension 125 mg/5 mL, 250 mg/5 mL
  • Tablet 125 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Pyrantel pamoate. https://www.mims.com/philippines/drug/info/pyrantel?mtype=generic Accessed January 24, 2021

Combantrin https://www.mims.com/philippines/drug/info/combantrin Accessed January 24, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jan 24
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