Ubidecarenone (Coenzyme Q10, CoQ10)

Ubidecarenone, also known as coenzyme Q10 or CoQ10, is a substance found in the human body, mainly in the heart, liver, kidneys, and pancreas. It has antioxidant properties and protects cells from damage by reactive oxygen species.

Ubidecarenone is an essential cofactor in the electron-transport chain in the mitochondria of all cells. The electron-transport chain is responsible for synthesizing large amounts of energy “currency” known as ATP (adenosine triphosphate), which is necessary for a multitude of cellular functions.

Uses

What is ubidecarenone used for?

• Angina pectoris
• Heart conditions (e.g. congestive heart failure)
• Statin-induced myopathy
• Coenzyme deficiency
• Mitochondrial disorders
• Diabetes
• Parkinson’s disease
•  Migraines
• Improving physical performance

How should I take ubidecarenone?

Read the directions on the packaging for complete information. Check the label and expiration date.

For oral dosage forms, swallow it whole without chewing, crushing, or dissolving it in liquid.

How do I store ubidecarenone?

Store this product at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using ubidecarenone?

Before using this drug, tell your doctor if you are/have:

• Pregnant or breastfeeding.
• Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
• An allergy to any of the ingredients of this product.
• Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side Effects

What side effects can occur from ubidecarenone?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

• Gastrointestinal discomfort
• Loss of appetite
• Nausea
• Diarrhea
• Skin rash
• Heartburn
• Dizziness
• Insomnia
• Abnormal liver function tests

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with ubidecarenone?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. 

Drugs with known interactions:

• Statin drugs
• Anticoagulants (e.g. warfarin)

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with ubidecarenone?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with ubidecarenone?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Angina pectoris

Take 150 to 600 mg in divided doses.

Heart failure

Take 50 to 150 mg every day in 2 to 3 divided doses.

What is the dose for a child?

There is no established pediatric dose. Therefore, it is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is ubidecarenone available?

This drug is available in the following brands, dosage forms, and strengths:

• GNC Coenzyme Q10 150 mg soft-gel capsules
• Nu Qten 100mg soft-gel capsules
• Qten 30 mg, 60 mg soft-gel capsules

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.