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Isordil (isosorbide dinitrate)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Isordil is a brand name of the drug isosorbide dinitrate. Isosorbide dinitrate is used to treat heart conditions such as congestive heart failure (CHF) and angina pectoris. It works by dilating the blood vessels (vasodilation) near the heart, allowing better blood flow. This drug requires a prescription from a doctor.



Uses of Isordil

Isordil is used to treat or prevent the following conditions:

  • Congestive heart failure (CHF)
  • Angina pectoris (chest pain due to heart disease)
  • Increased left ventricular end diastolic pressure

How should I take Isordil?

This medication should be taken on an empty stomach, preferably 30 minutes before meals.

It is available as a sublingual tablet and oral tablet. For the oral tablet, it should be swallowed whole without chewing or crushing it. The sublingual tablet should be placed under the tongue and dissolved slowly in the mouth. Do not swallow or chew the sublingual tablet.

How do I store Isordil?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of isosorbide dinitrate that may have different storage needs.

Additionally, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult a pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Isordil?

Before taking this medication, tell your doctor or pharmacist if:

  • You are allergic to triamterene or hydrochlorothiazide
  • You have any other allergies
  • Your medical history

Isordil is contraindicated or to be used with caution in the following conditions:

  • Pregnancy
  • Lactation or breastfeeding
  • Hypotension
  • Uncontrolled hypertension
  • Hypertrophic cardiomyopathy
  • Allergy to nitrates
  • Kidney disease
  • Erectile dysfunction

Is it safe during pregnancy or breastfeeding?

Unfortunately, the isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Therefore, always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Isordil?

Like all medicines, Isordil can cause side effects, including:

  • Vascular headaches
  • Flushing or paleness
  • Hypotension (low blood pressure)
  • Transient dizziness and weakness
  • Cerebral ischemia
  • Postural hypotension
  • Rash or dermatitis

Not everyone experiences these side effects. Additionally, there may be other side effects not listed above. If you have any concerns about a side effect, consult your doctor or pharmacist.


What drugs may interact with Isordil?

Isordil may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

These products include:

  • Sildenafil and other erectile dysfunction medications
  • Antihypertensive or blood pressure lowering medications
  • Beta-blockers
  • Phenothiazines
  • Riociguat
  • Garlic supplements

Does food or alcohol interact with Isordil?

Isosorbide dinitrate should not be taken together with alcohol. This is because alcohol can further reduce blood pressure, leading to severe hypotension. The presence of food can lessen absorption of isosorbide dinitrate in the body. So, it is best to take it on an empty stomach.

If you have concerns about possible food interactions while taking this drug, talk to your doctor or a pharmacist.

What health conditions may interact with Isordil?

This drug may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Inform your doctor if you have any of the following conditions:

  • Kidney disease
  • Hypertension
  • Hypotension
  • Erectile dysfunction
  • Enlarged heart


The information provided is not a substitute for any medical advice. That is why you should always consult with your doctor or pharmacist before using this drug.

What is the dose for an adult?

Angina pectoris

As an oral tablet, take 5 to 30 mg, four times a day.

As a sublingual tablet, take 5 to 10 mg, every 2 to 3 hours at the onset of an attack (angina pectoris). You may take 5 to 10 mg before possible triggers or stressors of angina, such as physical activity and emotional stress.

Acute congestive heart failure

As an oral tablet, take 10 to 40 mg, four times a day or as needed.

As a sublingual tablet, take 5 to 10 mg every 2 hours, or as needed.

Chronic heart failure

Start with 5 to 10 mg sublingual tablets every 2 hours or as needed. For maintenance, take 20 to 40 mg of oral tablets every 4 hours, or as needed.

What is the dose for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Isordil available?

Isordil is available in the following dosage forms and strengths:

  • Oral tablet 10 mg
  • Sublingual tablet 5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Isordil https://www.mims.com/philippines/drug/info/isordil Accessed May 28, 2021

Isosorbide Dinitrate https://www.mims.com/philippines/drug/info/isosorbide%20dinitrate Accessed May 28, 2021

Isosorbide Dinitrate (Oral Route, Sublingual Route) https://www.mayoclinic.org/drugs-supplements/isosorbide-dinitrate-oral-route-sublingual-route/proper-use/drg-20072904 Accessed May 28, 2021

Isosorbide dinitrate https://www.uofmhealth.org/health-library/d00268a1 Accessed May 28, 2021

Isosorbide dinitrate https://pubchem.ncbi.nlm.nih.gov/compound/Isosorbide-dinitrate Accessed May 28, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated May 28