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Cefpodoxime (cephalosporin, antibiotic)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Cefpodoxime is part of a class of antibiotics known as cephalosporins, specifically the 3rd generation of cephalosporins. Cephalosporins are chemically-related to penicillin and work by binding to penicillin-binding proteins (PBPs) that are embedded on certain bacterial cell walls. This binding prevents normal crosslinking and results in a weakened cell wall that ruptures and kills the bacteria. Cephalosporins have the added property of β-lactamase resistance, which increases their efficacy against certain bacteria.

cefpodoxime

Uses

What is cefpodoxime used for?

It is a broad-spectrum antibiotic that treats the following bacterial infections:

  • Respiratory tract infections (RTIs)
  • Urinary tract infections (UTIs)
  • Skin and soft tissue infections
  • Uncomplicated gonorrhea

The antimicrobial spectrum of activity of amoxicillin includes most Gram-positive and Gram-negative bacteria, except:

  • Pseudomonas aeruginosa
  • Enterococcus
  • Bacteroides fragilis

How should I take cefpodoxime?

Cefpodoxime is available as an oral suspension and tablet. Swallow the tablet whole without chewing or crushing it. Reconstitute (mix) the powder suspension with clean drinking water before use. Cefpodoxime should be taken with food, followed by a glass of water.

How do I store cefpodoxime?

This product is best stored at room temperature away from direct light and moisture. Keep reconstituted suspensions in the refrigerator (2-8°C) for up to 10 days. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product

Precautions & warnings

What should I know before using cefpodoxime?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur when using cefpodoxime?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Nausea, vomiting
  • Diarrhea
  • Diaper or skin rash
  • Mild allergic reaction
  • Vaginal infection
  • Nosebleed
  • Nightmares
  • Anxiety
  • Tinnitus

Rare, serious adverse reactions:

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with cefpodoxime?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Antacids
  • Probenecid

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with cefpodoxime?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Food improves the bioavailability of this drug. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with cefpodoxime?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Renal impairment
  • Clostridium difficile-associated diarrhea

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Respiratory tract infections and urinary tract infections

  • Take 100-200 mg every 12 hours.

Skin and soft tissue infections

  • Take 200-400 mg every 12 hours.

Uncomplicated gonorrhea

  • Take 200 mg as a single dose

What is the dose for a child?

Respiratory tract infections and urinary tract infections

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

Skin and soft tissue infections

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

Acute otitis media

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

How is cefpodoxime available?

This drug is available in the following brands, dosage forms, and strengths:

  • Switch film-coated tablet 200 mg
  • Trizef film-coated tablet 100 mg
  • Trizef granules for oral suspension 50 mg/5 mL
  • Zuderm film-coated tablet 100 mg, 200 mg
  • Zuderm granules for oral suspension 50 mg/5 mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose. Avoid missing doses to prevent antibiotic resistance and treatment failure.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Cefpodoxime https://www.mims.com/philippines/drug/info/cefpodoxime?mtype=generic Accessed June 25, 2021

Cefpodoxime https://www.uofmhealth.org/health-library/d00095a1 Accessed June 25, 2021

Cefpodoxime (Oral Route) https://www.mayoclinic.org/drugs-supplements/cefpodoxime-oral-route/precautions/drg-20073381?p=1 Accessed June 25, 2021

Cefpodoxime http://www.antimicrobe.org/drugpopup/Cefpodoxime.htm Accessed June 25, 2021

Cefpodoxime. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 25, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 25
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