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Cefadroxil (cephalosporin, antimicrobial agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Cefadroxil is part of a class of antibiotics known as cephalosporins, specifically a first-generation cephalosporin. Cephalosporins are chemically related to penicillin, and work by binding to penicillin-binding proteins (PBPs) that are embedded on certain bacterial cell walls. This binding prevents normal crosslinking and results in a weakened cell wall that ruptures and kills the bacteria.

Cephalosporins have the same mechanism as penicillin, however, have enhanced resistance against β-lactamases.

cefadroxil

Uses

What is cefadroxil used for?

Cefadroxil is a broad-spectrum antibiotic mainly indicated for:

  • Skin and skin structure infections
  • Urinary tract infections (UTIs)
  • Pharyngitis
  • Tonsillitis

How should I take cefadroxil?

Cefadroxil is available as an oral capsule and syrup. The oral capsule should be taken by mouth and swallowed whole, without chewing or crushing. The oral syrup should be measured with a medical-grade cup or spoon. This medication can be taken with or without food.

How do I store cefadroxil?

This product is best stored at controlled room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using cefadroxil?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product or other cephalosporins and pencillins.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur when using cefadroxil?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Nausea, vomiting
  • Diarrhea
  • Colitis
  • Mild allergic reaction

Rare, serious adverse reactions:

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with cefadroxil?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol)
  • Warfarin
  • Sodium picosulfate
  • BCG, typhoid, and other live vaccines
  • Fosphenytoin and phenytoin
  • Probenecid
  • Aminoglycosides
  • Polymyxin B
  • Colistin
  • Loop diuretics
  • Oral contraceptives
  • Cholestyramine

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with cefadroxil?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. There are no notable interactions with alcohol, however, a disulfiram-like reaction is possible with other cephalosporins. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with cefadroxil?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • History of hypersensitivity to penicillins
  • Renal impairment
  • GI disease
    • Colitis
    • Clostridium difficile-associated diarrhea
  • Seizure disorder

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Susceptible infections

  • Administer 1 to 2 g per day as a single dose or in 2 divided doses

Dose adjustment for renal impairment

Patients undergoing dialysis: administer and additional 0.5 to 1 g after each dialysis session

Creatinine clearance (CrCl)

  • < 10: administer 0.5 to 1 g every 36 hours
  • 11-25: administer 0.5 to 1 g every 24 hours
  • 26-50: administer 0.5 to 1 g every 12 hours

What is the dose for a child?

Susceptible infections

Administer 1 to 2 g per day as a single dose or in 2 divided doses

  • Ages >6 years or <40 kg bodyweight: administer 30-50 mg/kg per day as a single dose or in 2 divided doses
  • Maximum dose: up to 100 mg/kg per day

How is cefadroxil available?

This drug is available in the following brands, dosage forms, and strengths:

  • Drozid capsule 500 mg
  • Drozid syrup 125 mg/5 mL
  • Wincocef-500 capsule 500 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose. Avoid missing doses to prevent antibiotic resistance and treatment failure.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Cefadroxil https://www.mims.com/philippines/drug/info/cefadroxil?mtype=generic Accessed June 21, 2021

Cefadroxil http://www.antimicrobe.org/drugpopup/cefadroxil.htm Accessed June 21, 2021

Cefadroxil (Oral Route) https://www.mayoclinic.org/drugs-supplements/cefadroxil-oral-route/side-effects/drg-20073247?p=1 Accessed June 21, 2021

Wincocef-500 https://www.mims.com/philippines/drug/info/wincocef-500/?type=brief Accessed June 21, 2021

Cefadroxil. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 21, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 21
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