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Candesartan (ARB, antihypertensive agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Candesartan belongs to a class of drugs called angiotensin-II receptor blockers (ARBs). It works by relaxing blood vessels so blood can flow more easily.

candesartan

Uses

What is Candesartan used for?

Candesartan is commonly used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat heart failure.

How should I take Candesartan?

Swallow the tablet whole without chewing, crushing, or dissolving in water. Take it with or without food.

How do I store Candesartan?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Candesartan?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breast-feeding?

Unfortunately, this drug should not be taken during pregnancy and breastfeeding. Generally, ARBs should be avoided in pregnant women. If you become pregnant while taking this drug, inform your doctor right away. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

This medication is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Candesartan?

Dizziness, tiredness, or lightheadedness may occur as your body adjusts to the medication. Runny nose

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Skin reactions
  • Dry cough
  • Dizziness
  • Headache
  • Muscle or joint pain
  • Low sodium levels
  • Increased liver enzymes
  • Nausea
  • Angioedema
  • Hypotension (low blood pressure)
  • Hyperkalemia (high potassium levels)
  • Kidney impairment

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Candesartan?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • High-dose diuretics
  • Anesthesia
  • Spironolactone
  • Potassium-containing drugs and supplements
  • Lithium
  • NSAIDs
  • Aliskiren **potentially fatal

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Candesartan?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Candesartan?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Hypertension

Start taking 8 mg once a day. Dose should be adjusted according to response.

For maintenance, continue taking 8 mg once a day, up to 32 mg per day as single or in 2 divided doses.

Patients with intravascular volume depletion, take 4 mg once a day.

Congestive Heart Failure

Start taking 4 mg once a day. The dose may be doubled at intervals of not more than 2 weeks, up to 32 mg per day.

Liver Dose Adjustments

  • Mild liver dysfunction (Child-Pugh A): No adjustment recommended.
  • Moderate liver dysfunction (Child-Pugh B): 8 mg orally once a day.
  • Severe liver dysfunction (Child-Pugh C): Data not available.

What is the dose of Candesartan for a child?

Hypertension

1 TO LESS THAN 6 YEARS:

  • Initial dose: 200 mcg/kg/day orally in 1 to 2 divided doses. May increase according to response to 50-400 mcg/kg/day.
  • Maintenance dose: 0.05 to 0.4 mg/kg/day orally in 1 to 2 divided doses

6 TO LESS THAN 17 YEARS:

Less than 50 kg body weight:

  • Initial dose: 4 to 8 mg/day orally in 1 to 2 divided doses
  • Maintenance dose: 2 to 16 mg/day orally in 1 to 2 divided doses

Greater than 50 kg body weight:

  • Initial dose: 8 to 16 mg/day orally in 1 to 2 divided doses
  • Maintenance dose: 4 to 32 mg/day orally in 1 to 2 divided doses

Renal Dose Adjustments

  • GFR 30 mL/min/1.73 m2 or greater: Data not available
  • GFR less than 30 mL/min/1.73 m2: Not recommended

How is Candesartan available?

Candesartan is available in the following brand(s), dosage forms, and strengths:

  • Atasart tablets: 8 mg, 16 mg
  • Torcand tablets: 8 mg, 16 mg
  • Casartan tablets: 8 mg, 16 mg
  • Candez tablets: 8 mg, 16 mg
  • Frepan tablets: 8 mg, 16 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Candesartan https://www.mims.com/philippines/drug/info/candesartan?mtype=generic Accessed June 23, 2021

Candesartan https://www.nhs.uk/medicines/candesartan/ Accessed June 23, 2021

Candesartan (Oral Route) https://www.mayoclinic.org/drugs-supplements/candesartan-oral-route/side-effects/drg-20068192?p=1 Accessed June 23, 2021

Candesartan https://pubchem.ncbi.nlm.nih.gov/compound/Candesartan Accessed June 23, 2021

Candesartan. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 23, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 23