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Aprovel (irbesartan; antihypertensive agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Aprovel is the brand name of the drug irbesartan. Irbesartan is an angiotensin II receptor blocker (ARB) which is used to lower blood pressure. Your doctor may have prescribed this medication to treat hypertension.

Aprovel

Uses

What is Aprovel used for?

Aprovel is commonly used for treating hypertension, renal disease in hypertensive type 2 diabetic patients.

How should I take Aprovel?

Do not crush, break, or chew the tablets. Swallow Aprovel whole with a glass of water.

Ask your health care provider any questions you may have about how to use medication.

How do I store Aprovel?

Aprovel is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Aprovel in the bathroom or the freezer. There may be different brands of Aprovel that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Aprovel down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product

Precautions & warnings

What should I know before using medication?

Consult with your doctor or pharmacist, if you are/have:

  • Pregnant or breastfeeding
  • Taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • An allergy to any of active or inactive ingredients of Aprovel or other medications.
  • Any other types of allergies, such as to foods, dyes, preservatives, or animals.

Is it safe during pregnancy or breastfeeding?

If you get pregnant while taking irbesartan, talk to your doctor as soon as possible. You will need to stop taking Aprovel during pregnancy, as there is evidence that it can harm the fetus. It is especially dangerous during the second and third trimesters.

In addition, animal studies have shown that irbesartan passes into breastmilk. Therefore, talk to your doctor about breastfeeding while taking this medication.

This medication pregnancy risk category 1st trimester – C; 2nd and 3rd trimesters – D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Aprovel?

Here are side effects may occur:

  • Dizziness
  • Nausea
  • Fatigue
  • Increased plasma creatine kinase
  • Orthostatic hypotension
  • Musculoskeletal pain
  • Hyperkalemia in type II diabetes with renal disease

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Aprovel?

Aprovel may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Aprovel may cause interactions with these medications, such as:

  • Potassium-sparing diuretics
  • Potassium supplements
  • Other antihypertensive agents
  • Lithium
  • NSAIDs
  • Aspirin

Does food or alcohol interact with Aprovel?

Aprovel may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Aprovel?

Aprovel may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as:

  • A history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an angiotensin-converting enzyme (ACE) inhibitor (e.g., lisinopril).
  • A history of heart problems (e.g., heart failure)
  • Blood vessel problems
  • Blood flow problems
  • Diabetes
  • Kidney problems
  • A history of stroke or recent heart attack
  • Being dehydrated
  • Have low blood volume
  • Electrolyte problems (e.g., high blood potassium levels, low blood sodium levels)
  • Are on a low-salt (sodium) diet
  • Undergoing dialysis

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Aprovel for an adult?

  • Initially 150mg once daily. Increase if necessary to 300mg once daily or add other antihypertensive medications.
  • Renal disease, initially 150mg once daily, titrate to 300mg once daily for maintenance.

What is the dose of Aprovel for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Aprovel available?

Aprovel is available in the following dosage forms and strengths

  • Film-coated tab 150 mg, 300 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Aprovel https://www.mims.com/philippines/drug/info/aprovel?type=full Accessed May 30, 2021

Irbesartan https://www.mims.com/philippines/drug/info/irbesartan?mtype=generic Accessed May 30, 2021

Aprovel, INN – Irbesartan https://www.ema.europa.eu/en/documents/product-information/aprovel-epar-product-information_en.pdf Accessed May 30, 2021

Irbesartan (Oral Route) https://www.mayoclinic.org/drugs-supplements/irbesartan-oral-route/description/drg-20064404 Accessed May 30, 2021

Irbesartan https://www.nhs.uk/medicines/irbesartan/ Accessed May 30, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD on May 03, 2020
Medically reviewed by Stephanie Nicole Nera, RPh, PharmD
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