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Amlodipine + Benazepril

Uses|Precautions & warnings|Side effects|Interactions|Dosage


What is Amlodipine + Benazepril used for?

Amlodipine + Benazepril is commonly used to treat high blood pressure. It works by relaxing blood vessels so that blood can flow more easily. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

How should I take Amlodipine + Benazepril?

Take this medication by mouth with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

It may take 1 to 2 weeks before you get the full benefit of this medication. Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase).

How do I store Amlodipine + Benazepril?

Amlodipine + Benazepril is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Amlodipine + Benazepril in the bathroom or the freezer. There may be different brands of Amlodipine + Benazepril that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Amlodipine + Benazepril down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Amlodipine + Benazepril?

Before taking this medication, tell your doctor or pharmacist if you are allergic to amlodipine or benazepril; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine); or to other ACE inhibitors (such as captopril, lisinopril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), liver disease, a certain structural heart problem (aortic stenosis).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Older adults may be more sensitive to the side effects of this drug, including dizziness, increases in potassium level, and change in the amount of urine (kidney problems).

Is it safe during pregnancy or breast-feeding?

Please always consult with your doctor to weigh the potential benefits and risks before taking this Amlodipine + Benazepril. This Amlodipine + Benazepril is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

It is not recommended to take this medication while pregnant. There is positive data that suggests taking this medication while pregnant can cause harm or deformities to a fetus. It should only be taken if the benefits greatly outweigh the risks, as determined by your physician.

Side effects

What side effects can occur from Amlodipine + Benazepril?

Dizziness or light-headedness may occur as your body adjusts to the medication. Dry cough or swelling hands/ankles/feet may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: fainting, fast/irregular/pounding heartbeat, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), signs of kidney problems (such as change in the amount of urine).

This product may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

Some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Amlodipine + Benazepril?

Amlodipine + Benazepril may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include: aliskiren, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), lithium, drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone), gold injections, sacubitril.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking benazepril. Make sure all your doctors know which medicines you are using.

Does food or alcohol interact with Amlodipine + Benazepril?

Amlodipine + Benazepril may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Amlodipine + Benazepril?

Amlodipine + Benazepril may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Amlodipine + Benazepril.

What is the dose of Amlodipine + Benazepril for an adult?

Dosage for high blood pressure

  • Adult dosage (ages 18–64 years)
    • Typical dosage: This ranges from 2.5 mg amlodipine/10 mg benazepril to 10 mg amlodipine/40 mg benazepril.
    • Dosage increases: Your doctor may change your dosage after 7–14 days based on your blood pressure goals.
  • Geriatric dosage (ages 65 years and older)
    • Typical starting dosage: 2.5 mg amlodipine/10 mg benazepril once daily

Special dosage considerations

For people with liver problems: Amlodipine/benazepril is processed by your liver. If your liver isn’t working well, more of the drug may stay in your body longer, putting you at risk for side effects. If you have severe liver problems, your doctor will likely start you on 2.5 mg amlodipine/10 mg benazepril.

For people with kidney problems: Your dosage of amlodipine/benazepril doesn’t need to be adjusted if you have mild or moderate kidney disease. If you have severe kidney disease, you shouldn’t use this drug.

What is the dose of Amlodipine + Benazepril for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Amlodipine + Benazepril available?

Amlodipine + Benazepril is available in the following brand(s), dosage forms, and strengths:

  • Lotrel(R) capsule: 2.5 mg amlodipine besilate + 10mg benazepril hydrochloride
  • Amlodipine and benazepril are also available as separate drugs which can be taken together

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Amlodipine + Benazepril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Amlodipine-Benazepril, Oral Capsule. https://www.healthline.com/health/amlodipine-benazepril-oral-capsule. Accessed January 3, 2017.

AMLODIPINE BESYLATE-BENAZEPRIL. https://www.webmd.com/drugs/2/drug-11524/amlodipine-benazepril-oral/details. Accessed January 3, 2017.

Amlodipine / benazepril Pregnancy and Breastfeeding Warnings. https://www.drugs.com/pregnancy/amlodipine-benazepril.html. Accessed January 3, 2017.

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Written by Stephanie Nicole Nera, RPh, PharmD on May 02, 2020
Medically reviewed by Stephanie Nicole Nera, RPh, PharmD