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Amlodipine + Benazepril (antihypertensive agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Amlodipinine + benazepril (amlodipine besylate and benazepril hydrochloride) are two type of antihypertension medications. Amlodipine is a calcium channel blocker while benazepril is an angiotensin-converting enzyme (ACE)-inhibitor. Both work to reduce blood pressure and relieve symptoms of hypertension.

amlodipine + benazepril

Uses

What is Amlodipine + Benazepril used for?

Amlodipine + benazepril is commonly used to treat high blood pressure. It works by relaxing blood vessels so that blood can flow more easily. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

How should I take Amlodipine + Benazepril?

Take this medication by mouth with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

How do I store Amlodipine + Benazepril?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Amlodipine + Benazepril?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Amlodipine is a pregnancy category C drug, however, benazepril is a category D drug. There is a risk for fetal harm if you take it while pregnant. Therefore, it is not safe to take this combination medication while pregnant. Minimal amounts of benazepril pass into breastmilk while it is unknown if amlodipine passes into breastmilk. It is best to avoid breastfeeding while taking this drug.

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Amlodipine + Benazepril?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Dry cough
  • Dry mouth (xerostomia)
  • Confusion
  • Edema
  • Headache
  • Asthenia
  • Fatigue
  • Insomnia
  • Mood disturbances
  • Decreased libido
  • Flushing
  • Hot flashes
  • Rash, dermatitis
  • Abdominal pain
  • Diarrhea, constipation
  • Hypokalemia (low potassium levels)
  • Muscle and joint pain
  • Increased urination or frequency

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Amlodipine + Benazepril?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Other antihypertensive drugs (e.g. beta blockers, ARBs)
  • Potassium supplements
  • Potassium-sparing diuretics
  • Aliskiren
  • NSAIDs
  • Immunosuppressants
  • Statins
  • Azole antifungals
  • Erythromycin
  • Diltiazem
  • Protease inhibitors
  • Rifampicin
  • Aurothiomalate

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Amlodipine + Benazepril?

Do not take this drug with alcohol, grapefruit juice, or St. John’s wort. These foods have known interactions with amlodipine and should be avoided.

What health conditions may interact with Amlodipine + Benazepril?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Hypertension

  • Adults: Start taking 2.5 mg/10 mg once a day, up to 10 mg/40 mg once a day.
  • Elderly: Start taking 2.5 mg/10 mg once a day.

Special dosage considerations

If you have severe liver problems, your doctor will likely start you on 2.5 mg amlodipine/10 mg benazepril. In severe kidney impairment (CrCl ≤30 mL/min), this drug should not be used.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Amlodipine + Benazepril available?

Amlodipine + Benazepril is available in the following brand(s), dosage forms, and strengths:

  • Lotrel capsule: 2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg, 5 mg/ 40 mg, 10 mg/20 mg, 10 mg/40 mg
  • Amlodipine and benazepril are also available as separate drugs which can be taken together

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Amlodipine + Benazepril https://www.mims.com/philippines/drug/info/amlodipine%20+%20benazepril?mtype=generic Accessed June 21, 2021

Amlodipine And Benazepril (Oral Route) https://www.mayoclinic.org/drugs-supplements/amlodipine-and-benazepril-oral-route/side-effects/drg-20062916 Accessed June 21, 2021

amlodipine and benazepril https://www.uofmhealth.org/health-library/d03829a1 Accessed June 21, 2021

Lotrel Prescribing Information https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020364s065lbl.pdf Accessed June 21, 2021

Amlodipine and Benazepril. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 21, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 21
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