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Spersacet C (Chloramphenicol + Sulfacetamide)

Disclaimer|Uses|Precautions & Warnings|Side effects|Interactions|Dosage


This drug or supplement is currently off-market or not available in the Philippines. The information provided here is for informational purposes only.


Uses of Spersacet C

Spersacet C is an antibiotic. It works by killing or slowing the growth of susceptible bacteria.

Spersacet C is commonly used for treating serious infections, typhoid fever, cholera, eye infections, bacterial infections of the outer ear, plague, and other conditions.

How should I take Spersacet C?

Parkinson's disease treatment guidelines

Take Spersacet C by mouth with or without food. Drink it with a full glass of water. Do not chew or crush.

How do I store Spersacet C?

This drug is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of Spersacet C that may have different storage needs. Therefore, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush it down the toilet or pour them into a drain unless instructed to do so. Additionally, throw away any expired product. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Spersacet C?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding.
  • You are taking any other medicines. This includes any OTC medications, such as herbal and complementary medicines.
  • You have allergy with any of the active or inactive ingredients.
  • You have any other illnesses, disorders, or medical conditions.

Use Spersacet C with extreme caution in children younger than 1 year. Safety and effectiveness in this age group have not been confirmed.

Use it with extreme caution in children younger than 10 years who have diarrhea or gastrointestinal infection.

Use it with extreme caution in infants because they may be more sensitive to the effects of chloramphenicol, resulting in “gray baby syndrome.”

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

Potential side effects

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

Rare, serious adverse reactions:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Confusion
  • Dark urine
  • Delirium
  • Depression
  • Headache
  • Fever, chills, or sore throat
  • Pain, redness, or swelling at the injection site
  • Symptoms of “gray baby syndrome”
    • Swelling of the abdomen
    • Pale or bluish skin color
    • Vomiting
    • Shock
    • Difficulty breathing
    • Refusal to nurse
    • Loose green stools
    • Limp or lax muscle tone
    • Hypothermia
  • Unusual bleeding or bruising
  • Unusual tiredness
  • Vision changes

You may experience some, none, or other side effects not mentioned above. If you experience serious adverse reactions, you must stop taking the drug immediately. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


What drugs may interact with Spersacet C?

Spersacet C may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Known drugs and associated interactions with this medication include:

  • Anticoagulants (e.g. warfarin)
    • Increased risk of bleeding
  • Hydantoins (e.g. phenytoin) or sulfonylureas (e.g. glyburide)
    • Increased risk of toxicity
  • Chemotherapeutics
    • Increased risk of bone marrow suppression

Does food or alcohol interact with Spersacet C?

It may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Spersacet C?

Spersacet C may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Anemia
  • Bone marrow problems
  • Liver disease
  • Kidney problems
  • Active infection


The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using this drug.

What is the dose for an adult?

The dose prescribed and how often the medicine needs to be taken depends on the severity of the infection. Chloramphenicol is usually taken four times a day.

Adults and elderly: the recommended dose is 500 mg every 6 hours to be taken by mouth.

What is the dose for a child?

The dosage has not been established in pediatric patients. Additionally, tt may be unsafe for your child. Please consult with your doctor or pharmacist for more information.

How is Spersacet C available?

Spersacet C is available in the following dosage forms and strengths:

  • Spersacet C 250 mg capsules

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Spersacet® C, https://www.mims.com/philippines/drug/info/spersacet%20c, Accessed Aug 20, 2020

Choramphenicol, https://www.nhs.uk/medicines/chloramphenicol/, Accessed Aug 20, 2020

https://www.mims.com/philippines/drug/info/sulfacetamide?mtype=generic, Accessed Aug 20, 2020

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jan 22