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Natrilix SR

Uses|Precautions & warnings|Side effects|Interactions|Dosage


What is Natrilix® (indapamide hemihydrate) used for?

Natrilix® is commonly used for treating high blood pressure alone or along with other medicines. It is also used to treat salt and water retention (edema) associated with congestive heart failure.

How should I take Natrilix® (indapamide hemihydrate)?

Use indapamide hemihydrate hemihydrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take indapamide hemihydrate hemihydrate by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Indapamide hemihydrate hemihydrate may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of indapamide hemihydrate hemihydrate and you are taking one dose daily, take the missed dose if you remember the same day. Skip the missed dose if you do not remember until the next day. Do not take two doses at once.

Ask your health care provider any questions you may have about how to use indapamide hemihydrate.

How do I store Natrilix® (indapamide hemihydrate)?

Natrilix® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Natrilix® in the bathroom or the freezer. There may be different brands of Natrilix® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Natrilix® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Natrilix® (indapamide hemihydrate)?

Do not use indapamide hemihydrate if:

  • You are allergic to any ingredient in indapamide hemihydrate or to a sulfonamide medicine (e.g., sulfamethoxazole).
  • You are unable to urinate.
  • You are taking ketanserin.

Contact your doctor or health care provider right away if any of these apply to you.

Important safety information is:

  • indapamide hemihydrate may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use indapamide hemihydrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • indapamide hemihydrate may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms.
  • Your doctor may check your blood electrolytes while you take indapamide hemihydrate to check for a fluid or electrolyte imbalance. Tell your doctor right away if you experience decreased urination; dry mouth; fainting; fast or irregular heartbeat; increased thirst; muscle pain, weakness, or cramping; restlessness; severe dizziness or drowsiness; stomach problems; or unusual tiredness or weakness.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
  • indapamide hemihydrate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to indapamide hemihydrate. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take indapamide hemihydrate before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients – indapamide hemihydrate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • indapamide hemihydrate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking indapamide hemihydrate.
  • Lab tests, including blood electrolyte, glucose, and uric acid levels, and kidney function, may be performed while you use indapamide hemihydrate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use indapamide hemihydrate with caution in the elderly; they may be more sensitive to its effects, especially low blood sodium or potassium.
  • indapamide hemihydrate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Is it safe during pregnancy or breastfeeding?


If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using indapamide hemihydrate while you are pregnant.


It is not known if this medicine is found in breast milk. Do not breastfeed while taking indapamide hemihydrate.

Side effects

What side effects can occur from Natrilix® (indapamide hemihydrate)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Back pain
  • Constipation
  • Diarrhea
  • Dizziness or lightheadedness when siting up or standing
  • Drowsiness
  • Headache
  • Nausea
  • Nervousness
  • Runny nose
  • Trouble sleeping
  • Upset stomach
  • Vomiting
  • Weakness

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Photosensitivity
  • Blurred vision
  • Chest pain
  • Dark urine
  • Decreased urination or urination problems
  • Dry mouth
  • Fainting
  • Fast heartbeat
  • Fatigue
  • Fever, chills, cough, or sore throat
  • Increased thirst
  • Loss of appetite
  • Numbness of the hands or feet
  • Pale stools
  • Red, swollen, blistered, or peeling skin
  • Severe or persistent dizziness, drowsiness, or lightheadedness
  • Severe stomach pain
  • Swelling of the hands, ankles, or feet
  • Symptoms of low blood potassium (e.g., irregular heartbeat; muscle pain, weakness, or cramping)
  • Symptoms of low blood sodium (e.g., confusion, mental or mood changes, seizures, sluggishness)
  • Unusual bruising or bleeding
  • Unusual tiredness or weakness
  • Yellowing of the skin or eyes

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects.


What drugs may interact with Natrilix® (indapamide hemihydrate)?

Natrilix® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some medicines may interact with indapamide hemihydrate are:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) because they may decrease indapamide hemihydrate’s effectiveness.
  • Angiotensin-converting enzyme (ACE) inhibitors (e.g., enalapril) because the risk of kidney problems may be increased.
  • Diazoxide because the risk of high blood glucose levels, high uric acid levels, or low blood pressure may be increased.
  • Adrenocorticotropin hormone (ACTH) or corticosteroids (e.g., prednisone) because they may increase the risk of indapamide hemihydrate’s side effects.
  • Amantadine, antineoplastic agents (e.g., cyclophosphamide), digitalis glycosides (e.g., digoxin), ketanserin, lithium, or other blood pressure medicines because the risk of their side effects may be increased by indapamide hemihydrate.

Does food or alcohol interact with Natrilix® (indapamide hemihydrate)?

Natrilix® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Natrilix® (indapamide hemihydrate)?

Natrilix® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Heart problems (e.g., irregular heartbeat, heart failure)
  • Liver problems (e.g., cirrhosis)
  • Kidney disease
  • Gout
  • Lupus
  • Urinating problems
  • Low blood levels of sodium or potassium
  • A low-salt (sodium) diet
  • Neurosurgical procedure (sympathectomy)
  • Parenteral fluids


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Natrilix® (indapamide hemihydrate).

What is the dose of Natrilix® (indapamide hemihydrate) for an adult?


The adult starting dose is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after four weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after four weeks, the daily dose may be increased to 5 mg taken once daily, but adding another antihypertensive should be considered.

Edema of congestive heart failure:

The adult starting dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be increased to 5 mg taken once daily.

If the antihypertensive response is insufficient, indapamide hemihydrate may be combined with other antihypertensive drugs, with careful monitoring of blood pressure. It is recommended that the usual dose of other agents be reduced by 50% during initial combination therapy. As the blood pressure response becomes evident, further dosage adjustments may be necessary.

In general, doses of 5 mg and larger have not appeared to provide additional effects on blood pressure or heart failure, but are associated with a greater degree of hypokalemia. There is minimal clinical trial experience in patients with doses greater than 5 mg once a day.

What is the dose of Natrilix® (indapamide hemihydrate) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Natrilix® (indapamide hemihydrate) available?

Natrilix® is available in the following dosage forms and strengths:

  • Natrilix® SR tablet: 1.5mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Natrilix®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Indapamide. https://www.drugs.com/cdi/indapamide.html. Accessed November 11, 2016

Natrilix® (indapamide) 2.5mg tablets. https://www.drugs.com/uk/Natrilix® (indapamide) -2-5mg-tablets-leaflet.html. Accessed November 11, 2016

Indapamide. http://www.webmd.com/drugs/2/drug-12360/indapamide-oral/details. Accessed November 11, 2016.

Picture of the author
Written by Stephanie Nicole Nera, RPh, PharmD on May 02, 2020
Medically reviewed by Stephanie Nicole Nera, RPh, PharmD