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Dopamine hydrochloride (dopamine HCl)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Uses

Uses of dopamine hydrochloride

Dopamine hydrochloride (dopamine HCl) is commonly used for the treatment of hemodynamic status in patients with shock syndrome caused by heart attack, trauma, open-heart surgery, renal failure, congestive heart failure, and other causes. This drug improves urine flow, blood pressure, blood flow to vital organs, and heart function.

dopamine hydrochloride

How should I take dopamine hydrochloride?

For intravenous injection, the appropriate dose must be calculated. Read the label carefully before administering this drug. Additionally, consult your doctor for any information on the label that you do not clearly understand.

Proper storage conditions

Store at room temperature, away from moisture and direct sunlight. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of this drug that may have different storage needs. Therefore, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush it down the toilet or pour them into a drain unless instructed to do so. Additionally, do not use it if expired. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using dopamine hydrochloride?

Before using dopamine hydrochloride, tell your doctor if you have:

  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals;
  • Pediatric;
  • Geriatric;
  • Used any other health conditions, drugs that have a risk of interaction with dopamine hydrochloride as listed below.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this drug during pregnancy or while breastfeeding. Therefore, always consult with your doctor to weigh the potential benefits and risks before taking lysine. Lysine is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from dopamine hydrochloride?

As with taking other medicines, taking dopamine hydrochloride can cause some side effects. Most of them are uncommon and do not need any additional treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Increased heart rate
  • Arrhythmias
  • Changes in blood pressure
  • Dyspnea
  • Nausea
  • Vomiting
  • Headache
  • Increased blood urea nitrogen

Not everyone experiences these side effects while some may experience side effects not mentioned here. If you have any concerns about side effects, please consult your doctor or pharmacist.

Interactions

What drugs may interact with dopamine hydrochloride?

Dopamine hydrochloride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some drugs that may interact with dopamine HCl:

  • Alpha-blockers
  • Beta-blockers (e.g. metoprolol)
  • Phenytoin
  • Diuretics
  • Monoamine oxidase inhibitors (MAOIs)
  • Ergot alkaloids
  • Tricyclic antidepressants (e.g. amitriptyline)
  • Cyclopropane and halogenated hydrocarbon anesthetics

Does food or alcohol interact with dopamine hydrochloride?

Dopamine hydrochloride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dopamine hydrochloride?

For patients with pheochromocytoma, hyperthyroidism, uncorrected tachyarrhythmias or ventricular fibrillation, dopamine may not be suitable. This may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this drug.

What is the dose of dopamine hydrochloride for an adult?

Consult your doctor for information about the dose of dopamine hydrochloride. Recommended doses in some cases are listed below:

  • To increase urine output and kidney blood flow: take a low dose of 1 to 5 mcg/kg/minute IV.
  • To increase kidney blood flow, cardiac output and contractility, and heart rate: take an intermediate dose of 5 to 15 mcg/kg/minute IV.
  • IV to increase blood pressure and stimulate vasoconstriction: take a high dose of 20 to 50 mcg/kg/minute and can increase by 1 to 4 mcg/kg/minute at 10 to 30 minutes intervals until desired response is achieved.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. Therefore, it is always important to consult with your doctor or pharmacist for more information.

How is dopamine hydrochloride available?

This drug is available in the following dosage forms and strengths:

  • Solution for infusion: 40 mg/mL
  • Dopamine HCl in 5% dextrose solution (premixed) infusion: 200 mg/12.5 mg, 400 mg/12.5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Dopamine https://www.mims.com/philippines/drug/info/dopamine?mtype=generic Accessed January 25, 2021

Dopamine hydrochloride https://pubchem.ncbi.nlm.nih.gov/compound/Dopamine-hydrochloride#section=Depositor-Supplied-Synonyms Accessed January 25, 2021

DOPamine HYDROCHLORIDE AND 5% DEXTROSE INJECTION, USP https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/018132s067,018826s045lbl.pdf Accessed January 25, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD on May 02, 2020
Medically reviewed by Stephanie Nicole Nera, RPh, PharmD
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