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Update Date 03/12/2020 . 6 mins read
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What is Inoflox® used for?

Inoflox® (ofloxacin) is part of a class of antibiotics known as quinolones, specifically fluoroquinolones. Quinolones work by inhibiting an enzyme called DNA gyrase which is essential for bacterial DNA replication. Inhibition of normal replication, repair, and other processes results in bacterial cell death.

It is mainly indicated to treat the following bacterial infections:

  • Acute bacterial exacerbations of chronic bronchitis
  • Community-acquired pneumonia (CAP)
  • Uncomplicated dermal infections
  • Non-gonococcal urethritis and cervicitis
  • Acute pelvic inflammatory disease
  • Uncomplicated cystitis
  • Acute uncomplicated pyelonephritis
  • Complicated urinary tract infections (UTI)
  • Prostatitis
  • Enteric infections (including typhoid fever and shigellosis)

The antimicrobial spectrum of activity of ofloxacin includes:

Aerobic Gram-positive bacteria

  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • Streptococcus pyogenes

Aerobic Gram-negative

  • Citrobacter koseri
  • Enterobacter aerogenes
  • Escherichia coli
  • Haemophilus influenzae
  • Klebsiella pneumoniae
  • Neisseria gonorrhoeae
  • Proteus mirabilis
  • Pseudomonas aeruginosa
  • Shigella spp.
  • Salmonella typhi
  • Yersinia enterocolitica

Other microorganisms

  • Chlamydia trachomatis
  • Mycobacterium tuberculosis

How should I take Inoflox®?

Inoflox® is available as a vial with a solution for IV infusion and oral tablet. The IV solution is typically administered by a licensed health professional in a clinical setting. It should only be administered via slow IV infusion over a period of 30-60 minutes.

The oral tablets should be taken by mouth without chewing or crushing them. The tablets can be taken with or without food, followed by a glass of water. Avoid drinking milk, taking antacids that contain magnesium or aluminum, or taking supplements that contain iron or zinc 2 hours before or after taking ofloxacin.

When receiving either dosage form of this drug, it is important to stay well-hydrated to prevent the formation of highly concentrated urine.

How do I store Inoflox®?

This drug should be stored at room temperature (<30°C) and be protected from light. Do not allow this product to freeze. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using Inoflox®?

Fluoroquinolones, including ofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, or lung transplants.

Fluoroquinolones, including ofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid ofloxacin in patients with a known history of myasthenia gravis.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to ofloxacin or other fluoroquinolones
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category C drug. There are no adequate and well-controlled studies using ofloxacin in pregnant women. Since fluoroquinolones cause arthropathy (joint disease) in immature mammals, the drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug is excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using Inoflox®?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea
  • Insomnia
  • Headaches
  • Dizziness
  • Diarrhea
  • Vomiting
  • Rash and pruritis
  • External genital pruritis (in women)
  • Vaginitis
  • Altered sense of taste
  • Hypersensitivity reactions

Seek medical attention immediately if you experience any of these serious drug reactions:

  • Severe hypersensitivity reaction
    • Fever
    • Toxic epidermal necrolysis (TEN) or Stevens-Johnson Syndrome (SJS)
    • Vasculitis
    • Serum sickness
  • Tendon pain (tendinitis)
  • Muscle pain (myalgia)
  • Joint pain (arthralgia)
  • Hepatitis
  • Hematologic abnormalities
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Agranulocytosis
    • Pancytopenia

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


What drugs may interact with Inoflox®?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Known drugs and their interactions with ofloxacin include:

  • Metal cations
  • Antacids
  • Didanosine
  • Multivitamins
  • Antidiabetic medications
  • Aminoglycosides
  • Antituberculosis medications
  • Β-lactam antibiotics
  • Corticosteroids
  • Antiarrhythmic agents (class IA & III)
  • Macrolides
  • Antipsychotics
  • Tricyclic antidepressants
  • Furosemide
  • Methotrexate
  • NSAIDs
  • Probenecid
  • Theophylline
  • Warfarin

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with Inoflox®?

The oral form of this drug should be taken on an empty stomach for optimal absorption. However, the absorption rate is only slightly decreased with food so it can be taken with meals if desired. There are no notable interactions with alcohol with this drug.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with Inoflox®?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Myasthenia gravis
  • Adolescents under 18 years
  • Adults over 60 years
  • Conditions that require corticosteroid therapy
  • History of organ transplantation

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Inoflox®.

What is the dose of Inoflox® for an adult?

For respiratory and uncomplicated skin infections

  • Oral/IV: administer 400 mg every 12 hours for 10 days.

For cervicitis or urethritis due to Chlamydia trachomatis

  • Oral/IV: administer 300 mg every 12 hours for 7 days.

For acute pelvic inflammatory disease

  • Oral/IV: administer 400 mg every 12 hours for 10 to 14 days

For uncomplicated urinary tract infections

  • Cystitis due to coli or K. pneumoniae: administer 200 mg every 12 hours for 3 days
  • Cystitis due to other susceptible bacteria: 200 mg every 12 hours for 7 days
  • Acute pyelonephritis: administer 400 mg every 12 hours for 14 days
  • UTI: administer 200 mg every 12 hours for 14 days

For prostatitis

  • Oral/IV: administer 300 mg every 12 hours for 6 weeks

For typhoid fever

  • Oral/IV: administer 15 mg/kg/day in 2 divided doses (maximum daily dose: 800 mg) every 12 hours for 5 to 14 days

For shigellosis

  • Oral/IV: administer 200 mg every 8 hours for one day, or;
  • Oral/IV: administer 400 mg as a single dose

Dose adjustments for patients with renal impairment

  • CrCl 20-50 mL/min: no change to the dose, change frequency to once a day
  • CrCl <20 mL/min: reduce the dose by half and change the frequency to once a day

What is the dose of Inoflox® for a child?

Fluroquinolones such as ofloxacin are not recommended for use in children. It may cause bone, joint, and tissue damage and should not be given to children younger than 18 years. Consult with a doctor or pharmacist for alternatives and more information.

How is Inoflox® available?

This drug is available in the following dosage forms and strengths:

  • Oral tablets 200 mg, 400 mg
  • Solution for infusion 200 mg/100 mL

What should I do in case of an emergency or overdose?

Clinical features of acute overdosage of ofloxacin may include CNS symptoms such as confusion, dizziness, impairment of consciousness, and convulsive seizures, as well as GI reactions such as nausea and mucosal erosions.

In the event of overdose, symptomatic treatment should be implemented. The patient should be observed, and proper hydration maintained. ECG monitoring should be undertaken because of the possibility of QT interval prolongation.

Gastric lavage or induction of emesis may be used to empty the stomach. Elimination of ofloxacin may be increased by forced diuresis.

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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