You should not use Entresto if you have ever had a severe allergic reaction to a blood pressure medication such as:
- ACE inhibitors – benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril (Lotensin, Vasotec, Prinivil, Accupril, Mavik, and others)
- Other ARBs – azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan (Atacand, Avapro, Benicar, Diovan, Edarbi, Micardis, Teveten, and others)
You should not take Entresto within 36 hours before or after you have taken any ACE inhibitor medication.
If you have diabetes or kidney disease, do not use Entresto together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).
Is it safe during pregnancy or breastfeeding?
Do not take Entresto or other medications that contain valsartan, ARBs, or ACE inhibitors while pregnant. It is not recommended during the first trimester and it is contraindicated during the second and third trimesters of pregnancy. ACEIs and ARBs are known to be toxic to the fetus.
It is not known if Entresto is excreted in breastmilk. However, animal studies of valsartan and sacubitril showed that these drugs could pass into breastmilk. Because of this, it is not recommended for lactating mothers to breastfeed unless approved by a doctor or OB-GYN.
Side effects
What side effects can occur from Entresto?
Get emergency medical help if you have signs of an allergic reaction to Entresto: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Also call your doctor at once if you have:
- A light-headed feeling, like you might pass out
- Extreme tiredness
- High potassium – slow heart rate, weak pulse, muscle weakness, tingly feeling
- Kidney problems – little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath
Common side effects may include:
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