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Multiple Sclerosis Treatments and Interventions

Multiple Sclerosis Treatments and Interventions

Multiple sclerosis (MS) treatment, management, and interventions can be just as complicated as the disease itself. Because there is no single diagnostic test to determine if someone has MS, much of the treatment addresses symptoms rather than the disease itself. In fact, until now, the cure for multiple sclerosis has not been found.

Available treatment options

Multiple sclerosis is an autoimmune disease wherein the immune system attacks the protective layer of the brain cells and spinal cord. This layer, known as the myelin sheath, also speeds up impulse transmission from the brain to the rest of the body.

Like other autoimmune diseases, the treatment aims to suppress the immune response and slow down damage. There are many symptoms of MS, some of which include fatigue, weakness, tremors, hearing loss, bladder dysfunction, and breathing problems.

Multiple sclerosis can be relapsing-remitting, progressive, or progressive-remitting. Remitting means that symptoms go away, while relapsing means the symptoms come back. Progression means that the disease symptoms get worse over time. Treatment depends on the diagnosis. Because MS is a chronic disease, treatment is long-term, oftentimes lifelong.

Medications for MS treatment and interventions

Treatment of acute attacks

multiple sclerosis treatments and interventions

Glucocorticosteroids treat the initial attack or short exacerbations. Exacerbation happens when a patient encounters a trigger or stress that worsens symptoms. Steroids work by suppressing the immune system response which reduces the severity and duration of the attack.

Examples of corticosteroids used in MS are methylprednisolone, dexamethasone, and prednisone. One treatment approach is to give patients 500mg to 1g of intravenous methylprednisolone per day for 3 to 5 days. This may be followed-up with tapering doses of oral prednisone starting at 60 to 80 mg per day, and gradually reduced over 2 weeks.

Steroid treatment of acute attacks in MS treatment and interventions is generally short-term. Prolonged use of steroids can cause unwanted side effects such as decreased immunity, water-retention, weight gain, and osteoporosis.

Disease-modifying drugs

Disease-modifying drugs (DMDs) are mainly used in patients with relapsing forms of MS. In some cases, DMDs can be used to treat SPMS. This is due to overlapping symptoms.

Examples of DMDs are interferon-β, glatiramer acetate, monoclonal antibodies, and fingolimod. These drugs have different mechanisms but all work by altering the response of the immune system. Some of the cells in the immune system that are targeted by these drugs include T cells, APCs, and macrophages.

By modifying receptor binding DMDs reduce the autoimmune response toward the myelin. This slows down the destruction of the myelin, preventing the worsening of symptoms like weakness and spasms.

multiple sclerosis treatments and interventions

Interferon-β (both IFN-β-1a and IFN-β-2b) is available as an injectable. Glatiramer acetate is available as an injectable. Fingolimod reduces the attack rate and significantly improves all measures of disease severity in MS. It is available as an oral capsule.

Natalizumab is a monoclonal antibody. It is an IV infusion drug. Long-term use of natalizumab may carry the risk of developing progressive multifocal leukoencephalopathy (PML). It is a life-threatening condition resulting from infection by the John Cunningham (JC) virus.

Treatment of Symptoms

For symptoms of ataxia or tremors, clonazepam, primidone, propranolol, or ondansetron may help. Potassium channel blocker like 4-aminopyridine can help relieve weakness.

Use phenytoin, gabapentin, tricyclic antidepressants, or mexiletine to treat pain. Additionally, NSAIDs like ibuprofen or paracetamol are not effective for the type of pain associated with MS.

More often than not, patients with MS develop clinical depression. First, patients should seek counseling. Drugs used include selective serotonin uptake inhibitors (SSRIs), tricyclic antidepressants, and non-tricyclic antidepressants.

MS treatments and interventions

Non-medicinal MS treatments and interventions

To help with the medical treatment of MS and slow its progression, it’s best to consider some lifestyle changes as well. Thus, maintaining your overall health will improve your chances of remission and risk of infection.

While taking corticosteroids, patients should have a low-salt and potassium-rich diet. If a MS patient needs diuretics, potassium-sparing diuretics should be used.

MS treatments and interventions

An alternative MS treatment and intervention is plasma exchange or plasmapheresis. This treatment may be considered if the patient is unresponsive to steroids. However, plasma exchange can be expensive and is only available at limited hospitals in the Philippines.

Maintaining a healthy diet is important for people with MS. People with MS can experience gastrointestinal problems like dyspepsia and constipation. Eating a balanced diet that is low in fat and higher in fiber can help with these problems. Avoid consuming caffeine and alcohol.

Exercise should be done as tolerated. This may be hard for some patients with more advanced disease, but regular movement and stretching can improve muscle spasms. MS patients should have physical therapy.

Key takeaways

On a final note, it is important to remember that there is still no cure for multiple sclerosis. Despite this, there are numerous MS treatments and interventions available that can improve a patient’s quality of life. Above all, consult with your doctor to determine the best treatment plan for you.

Learn more about Multiple Sclerosis, here.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Harrison’s principles of Internal Medicine (19th edition.), Chapter 458, p. 2667-2673, Accessed November 4, 2020

Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis https://n.neurology.org/content/90/17/777 Accessed November 4, 2020

Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis https://n.neurology.org/content/82/12/1083 Accessed November 4, 2020

European and American Guidelines for Multiple Sclerosis Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283786/Accessed November 4, 2020

Types of Multiple Sclerosis https://mymsaa.org/ms-information/overview/types/ Accessed November 4, 2020

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Nov 13, 2020