Ibuprofen vs. Other OTC pain-relievers
Of course, ibuprofen for headache pain is not your only option. Other over-the-counter (OTC) medications such as paracetamol, aspirin, and mefenamic acid are also used to treat headaches and body pains.
Paracetamol vs. Ibuprofen
Paracetamol is another common drug for relieving pain and fever. However, it is technically not an NSAID because it has a different mechanism of action. Since paracetamol does not block the COX enzymes, it has little to no effect on inflammation. Additionally, it has no effect on blood clotting or bleeding times. Compared to ibuprofen, paracetamol carries a higher risk of liver toxicity when taken in high doses.
Headaches accompanied by fever may be treated with paracetamol alone or a combination of paracetamol and ibuprofen. However, if a disease such as dengue is considered, ibuprofen should be avoided as it can promote hemorrhaging. Paracetamol is also safer to use during pregnancy and before and after major surgeries.
Aspirin vs. Ibuprofen
Aspirin and ibuprofen both have the same mechanism of action as NSAIDs. The main difference is that aspirin is an irreversible blocker of the COX-1 and COX-2 enzymes, while ibuprofen is reversible. This means that both the positive and negative effects of aspirin are stronger and last longer. Aspirin is useful for headaches, mild body pain, and fever.
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