Moreover, recent research revealed that genetics play a role in 40-70% of obesity cases. Researchers also found out that there are more than 50 genes closely linked to obesity.
Below are some gene variants that may be associated with obesity:
- ADIPOQ (Adipocyte-, C1q-, and collagen domain-containing)
- FTO (Fat mass- and obesity-associated gene)
- LEP (Leptin)
- LEPR (Leptin receptor)
- INSIG2 (Insulin-induced gene 2)
- MC4R (Melanocortin 4 receptor)
- PCSK1 (Proprotein convertase subtilisin/kexin type 1)
- PPARG (Peroxisome proliferator-activated receptor gamma)
Several of these genes link to a phenomenon seen in a variety of other common conditions (monogenetic obesity). However, a significant proportion of obesity appears to depend on many factors. Gene expression is brought about by the result of complex interactions between genes and the environment.
Simply put, just because you have genes that are associated with obesity doesn’t automatically mean you will be obese.
Is obesity genetic? Yes, it can be genetic, but there are also a large number of factors that contribute to its overall prevalence. Behavior, lifestyle, and environmental setting may also contribute to being overweight or obese.
Understanding how genes come into play and how they lead to obesity can be helpful in finding better strategies for obesity prevention and treatment. Ultimately, it is important to keep in mind that genetic risk is just a small part of the equation. You can still take charge of other factors that lead to obesity by leading a healthy lifestyle.
Learn more about Obesity here.