Minocycline

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Update Date 11/05/2020 . 8 mins read
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Uses

What is Minocycline used for?

Minocycline is an antibiotic used to treat a wide variety of infections. It may also be used along with other medications to treat severe acne. This medication belongs to a class of drugs known as tetracycline antibiotics. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

How should I take Minocycline?

This medication may be taken with or without food. Take this medication by mouth as directed by your doctor, usually every 12 hours, at least 1 hour before or 2 hours after a meal. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If stomach upset occurs, taking it with food or milk may help. However, minocycline may not work as well if you take it with food or milk, so ask your doctor or pharmacist if you may take it that way. If you are taking the capsules, swallow them whole. Do not lie down for at least 10 minutes after taking this medication. For this reason, do not take it right before bedtime.

Take this medication 2 to 3 hours before or after taking any products containing aluminum, calcium, iron, magnesium, or zinc. Some examples include antacids, didanosine solution, quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice. These products bind with minocycline, preventing your body from fully absorbing the drug.

The dosage and length of treatment are based on your medical condition and response to treatment.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same times every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

How do I store Minocycline?

Minocycline is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Minocycline in the bathroom or the freezer. There may be different brands of Minocycline that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Minocycline down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Minocycline?

Before taking minocycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracyclines (such as doxycycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, trouble swallowing, esophagus problems (such as hiatal hernia or reflux/heartburn).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Minocycline may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children younger than 8 years may be more sensitive to the side effects of minocycline, especially tooth discoloration. Tooth discoloration has also occurred in older children and in young adults. Discuss the risks and benefits of this medication with the doctor.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using minocycline. Minocycline may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

This medication passes into breast milk in small amounts but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk. Please always consult with your doctor to weigh the potential benefits and risks before taking Minocycline. Minocycline is pregnancy risk category D according to the US Food and Drug Administration (FDA). 

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Minocycline?

Nausea, vomiting, diarrhea, lightheadedness, dizziness, or a feeling of spinning may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: painful/difficult swallowing, hearing changes (such as ringing in the ears, decreased hearing), joint stiffness/pain/swelling, signs of kidney problems (such as change in the amount of urine, pink urine), signs of liver problems (such as loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), yellow-gray-brown tooth discoloration, blue-gray skin/tongue/lips/gums).

Minocycline may rarely cause a serious increase in pressure inside the skull (intracranial hypertension-IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after minocycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: severe/lasting headache, vision changes (such as blurred/double vision, decreased vision, sudden blindness), nausea/vomiting that doesn’t stop.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn’t stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn’t go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Minocycline?

Some products that may interact with this drug are: retinoid medications taken by mouth (such as acitretin, isotretinoin), strontium, and calcium-containing preparations.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain lab tests (such as urine catecholamine levels), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Minocycline may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Minocycline?

Minocycline may interact with food or alcohol by altering the way the drug works or increasing the risk for serious side effects. Food that contains caffeine, calcium, magnesium, iron, and other metals can chelate or bind to tetracyclines, decreasing their absorption and effectiveness. Avoid consuming food and drinks that contain these within 1-2 hours before or 2-3 hours after taking this medication. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Minocycline?

Minocycline may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Minocycline.

What is the dose of Minocycline for an adult?

Usual Adult Dose for Susceptible Bacterial Infections

Intravenous

Initially, 200 mg followed by 100 mg twice a day. Max: 400 mg/day.

Oral

200 mg daily in divided doses.

Mycobacterium marinum infections

100 mg twice a day for 6-8 weeks

Asymptomatic meningococcal carriers

100 mg 12 twice a day for 5 days, followed by a course of rifampicin.

Acne

50 mg twice a day or 100 mg once daily. 

≥45 kg body weight: 1 mg/kg once daily as modified-release preparation.

Syphilis

200 mg initially, followed by 100 mg twice a day for 10-15 days.

Nongonococcal urethritis

100 mg twice a day for at least 7 days.

Uncomplicated gonorrhoea

Initially, 200 mg, followed by 100 mg twice a day for a min of 4 days, follow-up cultures should be done w/in 2-3 days after completion of therapy.

Uncomplicated urethral gonorrhoea in men

100 mg twice a day for 5 days.

Periodontitis

As extended-release powder: 

Insert the unit-dose cartridge subgingivally into the base of periodontal pocket as an adjunct to scaling and root planing. Each cartridge contains 1 mg of minocycline. This should be done by a dental healthcare provider and is not meant for self administration.

What is the dose of Minocycline for a child?

Usual Pediatric Dose for Susceptible Bacterial Infections

Intravenously
Over 8 years old: Initially, 4 mg/kg, then 2 mg/kg 12 hourly not to exceed the usual adult dose.

Not recommended for use in children under the age of 8 years. Tetracyclines may cause permanent damage to bones and discolor teeth.

How is Minocycline available?

Minocycline is available in the following dosage forms and strengths:

  • Minocin(R) capsule: 50 mg, 100 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Minocycline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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