Carbimazole

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Update Date 03/11/2020 . 4 mins read
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Know the basics

What is carbimazole used for?

Carbimazole is an anti-thyroid drug. It is used to treat hyperthyroidism. Overactive or overproductive thyroid glands can cause the neck to swell, forming a goiter. 

The drug carbimazole is also used to reduce the size of very large thyroid glands prior to surgery. This makes it easier to dissect and remove parts of the enlarged gland.

How should I take carbimazole?

Carbimazole is available as an oral tablet. The oral tablet should be taken by mouth without chewing or crushing it. The tablets can be taken with each meal, for your convenience.

How do I store carbimazole?

This drug should be stored at room temperature (<25°C) and be protected from light and moisture. For safety, keep out of the reach of children and pets.

Always check the label before using this product. Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Know the precautions & warnings

What should I know before using carbimazole?

Before using this medication, inform your doctor if you:

  • Have ever had an allergic reaction to carbimazole or other sulfonylureas or sulfonamides.
  • Have a history of allergy to other medications, food, or other substances.
  • Are taking other medications, especially other anti-thyroid drugs.
  • Have underlying health conditions, like liver damage.
  • Are pregnant or breastfeeding.

Is it safe to take carbimazole during pregnancy or breast-feeding?

Carbimazole is a pregnancy category D drug and should not be given to pregnant women unless the benefits outweigh the risks. There is positive evidence it causes fetal defects.

It passes into the placenta and breast milk. Breastfeeding is safe when the mother’s dose is low. At higher doses, breastfeeding should be stopped.

Side effects and interactions

What side effects can occur when using carbimazole?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or stopped.

Potential side effects while using this drug include:

  • Hypoglycemia
  • Nausea
  • Upset stomach
  • Loss of taste
  • Fever
  • Hepatitis
  • Jaundice
  • Hypersensitivity
  • Joint pain
  • Headaches
  • Rash
  • Itchiness
  • Hair loss
  • Bleeding

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Bone marrow depression
  • Agranulocytosis
  • Pancreatitis
  • Hemolytic anemia
  • Thrombocytopenia
  • Stevens-Johnson syndrome (SJS)

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with carbimazole?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using. Including prescription drugs, nonprescription drugs, and herbal products.

Drugs that are known to interact with carbimazole include:

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with carbimazole?

There are no notable interactions with food. This drug should not be taken with alcohol as it may increase the severity of hypoglycemia and liver damage.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with carbimazole?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Pre-existing blood disorders
  • Acute pancreatitis
  • Hepatic impairment
  • Tracheal obstruction
  • Require radio-iodine imaging
  • Intrathroacic goiter

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using carbimazole.

What is the dose of carbimazole for an adult?

For hyperthyroidism

  • Initially give 15-60 mg per day in 2-3 divided doses. Reduce the dose gradually once thyroid levels are normalized.
  • Maintenance dose: 5-15 mg per day as a single dose.
  • Blocking replacement: give 20-60 mg in 2-3 divided doses in combination with levothyroxine.
  • Treatment duration: 6 to 18 months

What is the dose of carbimazole for a child?

For hyperthyroidism

  • Ages 3 to 17 years: initially give 15 mg per day and adjust according to the response.

How is carbimazole available?

This drug is available in the following brands, dosage forms, and strengths:

  • Carbinom 5 mg and 10 mg tablets
  • NeoMercazole 5mg and 20 mg tablets
  • Neomerdin 5mg and 20 mg tablets
  • Neotrox 5 mg and 20 mg tablets

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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