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Uses|Precautions & warnings|Side effects|Interactions|Dosage


What is Covapril® (perindopril erbumine) used for?

Covapril® is commonly used for treating high blood pressure. It may be used alone or along with other medicines.

It is also used to reduce the risk of heart attack or death caused by heart problems in patients with stable coronary artery disease. It may also be used to treat other conditions as determined by your doctor.

How should I take Covapril® (perindopril erbumine)?

Use perindopril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take perindopril by mouth with or without food.

Take perindopril on a regular schedule to get the most benefit from it.

Taking perindopril at the same time(s) each day will help you to remember to take it.

Continue taking perindopril even if you feel well. Do not miss any doses.

Ask your health care provider any questions you may have about how to use perindopril.

How do I store Covapril® (perindopril erbumine)?

Covapril® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Covapril® in the bathroom or the freezer. There may be different brands of Covapril® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Covapril® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Covapril® (perindopril erbumine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Covapril® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor (e.g., lisinopril).
  • You have severe kidney problems.
  • You are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Covapril® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Covapril®. Covapril® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Covapril® (perindopril erbumine)?

Side effects may occur when using this drug, such as:

  • Headache
  • Dizziness
  • Vertigo
  • Paresthesia
  • Vision disturbances
  • Tinnitus
  • Hypotension
  • Cough
  • Dyspnea
  • GI disorders
  • Rash
  • Pruritus
  • Muscle cramps
  • Asthenia

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Covapril® (perindopril erbumine)?

Covapril® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug, including:

  • Diuretics
  • Lithium
  • K-sparing diuretics
  • K supplement or K-containing salt substitutes
  • NSAIDs
  • Antihypertensives & vasodilators
  • Antidiabetics
  • TCAs
  • Antipsychotics

Does food or alcohol interact with Covapril® (perindopril erbumine)?

Covapril® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Covapril® (perindopril erbumine)?

Covapril® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Covapril® (perindopril erbumine).

What is the dose of Covapril® (perindopril erbumine) for an adult?


The recommended dose is 4 mg once daily, may be increased to 8 mg once daily after 1 month.

Elderly: Start treatment at 2 mg, may be progressively increased to 4 mg after 1 month, then 8 mg if needed.

Symptomatic heart failure

The recommended dose is 2 mg, may be increased by 2-mg increments ≥2 wk to 4 mg once daily if tolerated.

What is the dose of Covapril® (perindopril erbumine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Covapril® (perindopril erbumine) available?

Covapril® is available in the following dosage forms and strengths:

  • Covapril® 4mg tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Covapril®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Covapril®. http://www.mims.com/malaysia/drug/info/Covapril. Accessed Mar 6, 2017

Perindopril. https://www.drugs.com/cdi/perindopril.html/. Accessed Mar 6, 2017.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Covapril®. http://www.mims.com/malaysia/drug/info/Covapril. Accessed Mar 6, 2017

Perindopril. https://www.drugs.com/cdi/perindopril.html/. Accessed Mar 6, 2017.

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Written by Stephanie Nicole Nera, RPh, PharmD on May 03, 2020
Medically reviewed by Stephanie Nicole Nera, RPh, PharmD