Is type 2 diabetes genetic? Studies of twins have shown that genetics might have some influences on type 2 diabetes., according to the American Diabetes Association. However, it is important to note that these studies were not totally conclusive because of the environmental influences that also increase the risk of type 2 diabetes risk. On their own, the contribution of each gene is relatively little, but. However, the more additional mutation you have, the higher your risks seem to increase.
Generally, your risks of type 2 diabetes will rise if you have mutations in the genes that control:
- Production of glucose
- Production of insulin
- How glucose levels are sensed in the body
- Regulation of insulin.
A number of genes have been identified to have a role in diabetes risk. Genes that have been associated with type 2 diabetes risk include:
- TCF7L2, which affects insulin secretion and glucose production;
- The sulfonyl urea receptor (ABCC8), which helps regulate insulin;
- Calpain 10, which is associated with type 2 diabetes risk in Mexican Americans;
- Glucose transporter 2 (GLUT2), which helps move glucose into the pancreas;
- The glucagon receptor (GCGR), a glucagon hormone involved in glucose regulation.
What are Genetic Tests for Type 2 Diabetes?
Even though there are tests available to detect diabetes gene mutations, the major risks depend much more on other predictors. These predictors including:
- Body mass index (BMI)
- High blood pressure
- Elevated triglycerides and cholesterol levels
- History of gestational diabetes
Is type 2 diabetes genetic? The interactions between genetics and the environment make it inconclusive to measure the actual part gene mutations play in causing type 2 diabetes. At the same time, having some genetic factors does not mean you are definitely sentenced to diabetes. With positive changes in lifestyle such as increased physical activity activities and weight loss, diabetes can be prevented.
While there genetic tests, in clinical practice, genetic testing for type 2 diabetes is not usually done. Consult your doctor.
Though diabetes is influenced by your genes, there are many things you can do to prevent it. You can adopt a healthier lifestyle that includes more exercise and proper diet. However, knowing and understanding your family history when it comes to diabetes is also crucial. It can help you seek medical intervention at the right time and help prevent disease progression.
Learn more about Diabetes here.
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