Carcinogens are a term that we hear pretty often, especially when people are talking about cancer. While most people know what carcinogens are, not a lot of people are aware of how do carcinogens cause cancer.
Read on to learn more about these chemicals, and why they cause people to develop cancer.
What Are Carcinogens?
Carcinogens are any substance that can induce cancer. Artificial sources such as cigarette smoke and certain chemicals are known carcinogens. But you can also find naturally occurring carcinogens such as aflatoxin in fungi1.
Another type of carcinogen is radiation, such as with x-rays, gamma rays, and even solar radiation from the sun.
Another characteristic of carcinogens is that some can cause more specific types of cancer. One example of this is asbestos. Back in the day, construction companies widely used asbestos as insulation and as a fireproof material. Workers who installed and used asbestos had developed a very specific type of cancer in the lungs called mesothelioma.
Another example is tamoxifen, which is a drug used to treat cancer. While useful in treating breast cancer because of its ability to block estrogen, this drug can increase the risk of uterine cancer as a consequence. So, although tamoxifen is an anti-cancer drug and estrogen is a natural hormone both are potentially carcinogenic.
But how do carcinogens cause cancer? What is in these substances that cause an abnormal growth of cancer cells?
How Do Carcinogens Cause Cancer?
In order to understand how carcinogens cause cancer, we need to talk about how people can get cancer in the first place.
In the absence of carcinogens, people can develop cancer when certain genetic changes happen during cell division. As a cell divides, the genes that govern what happens to the cell can randomly develop changes that leads to the creation of cancer cells2.
For carcinogens, they act as a substance that increases the risk or even triggers these mutations. If a person constantly interacts with carcinogens, then there’s a good chance that they will develop cancer as the carcinogen damages their DNA.
This is why people who smoke tend to develop lung cancer, since the cells in their lungs are exposed to the carcinogens found in tobacco smoke. The same thing goes for people who are exposed to the sun without any protection. This constant exposure can cause their skin cells to develop mutations which can lead to cancer.