Calamine is classified as a topical dermatological medicine for anti-inflammatory and antipruritic purposes. It comes in three formulations: local, topical, and lotion — the most common among the three is the lotion.
While this medication is commonly used for treating minor skin conditions, it has other uses as well. For example, since calamine lotions contain zinc oxide in them, they may provide some relief for acne.
Zinc oxide in calamine lotions helps in drying minor skin issues, specifically skin that is oozing after contact with poison ivy, poison sumac, or poison oak. Also, it has antimicrobial properties which can be effective in killing microorganisms such as bacteria, fungi, viruses, or protozoans.
Do take caution when using calamine for acne as few studies have been able to support any benefits. Calamine may even worsen acne due to its drying properties.