Tiaprofenic Acid

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Update Date 14/08/2020 . 5 mins read
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What is tiaprofenic acid used for?

Tiaprofenic acid is part of a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs), specifically a propionic acid-derived or profen NSAID. NSAIDs are used to treat various causes of pain, inflammation, and swelling. It can also aid in reducing fever.

NSAIDs work by blocking the action of either or both the COX-1 and COX-1 enzymes. These enzymes are responsible for converting arachidonic acid into prostaglandin, which is a group of substances that regulate many cellular processes such as platelet aggregation, vasodilation, gastric mucus secretion, and proinflammatory mediators.

Tiaprofenic acid is mainly indicated to treat the following conditions:

  • Ankylosing spondylitis
  • Pain and inflammation
  • Osteoarthritis
  • Rheumatoid arthritis

How should I take tiaprofenic acid?

Tiaprofenic acid is available as an oral tablet or capsule. The oral tablets and capsules should be taken by mouth without chewing or crushing it. The tablets should be taken with food to prevent gastric irritation.

How do I store tiaprofenic acid?

This drug should be stored at room temperature (<25°C) and be protected from light and moisture. Do not allow this product to freeze. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using tiaprofenic acid?

NSAIDs, including tiaprofenic acid, are associated with an increased risk of bleeding and gastric ulceration. This risk is further increased in older patients usually over 60 years of age, those taking blood thinners, and those with blood clotting disorders.

Some groups of people with conditions like asthma or allergic rhinitis may experience an exacerbation of symptoms after using NSAIDs.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to tiaprofenic acid or other NSAIDs
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other NSAIDs and blood thinners
  • You have underlying health conditions, such as asthma

Is it safe during pregnancy or breastfeeding?

This drug is not recommended for use during pregnancy and is contraindicated for use during the 3rd trimester. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using tiaprofenic acid?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea
  • Diarrhea
  • Stomach upset
  • Abdominal pain
  • Indigestion
  • Headache
  • Dizziness
  • Allergic reaction
    • Rash
    • Pruritis
  • Bronchospasm
  • Blood abnormalities
    • Bleeding
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Eosinophillia
  • Edema
  • Eye irritation
  • Photosensitivity
  • Urinary tract effects
    • Cystitis
    • Bladder irritation
    • Increased frequency
    • Dysuria
    • Blood in the urine
  • Tinnitus

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Gastrointestinal damage
    • Peptic ulceration
    • Bleeding
  • Severe hypersensitivity reaction
    • Toxic epidermal necrolysis (TEN)
    • Stevens-Johnson Syndrome (SJS)
  • Hepatitis
    • Jaundice
  • Nephrotoxicity

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


What drugs may interact with tiaprofenic acid?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with tiaprofenic acid include:

  • Other NSAIDs
    • GI distress
    • Ulceration
  • Salicylates
    • GI distress
  • Bisphosphonates
    • Increased gastric mucosal damage
  • Anticoagulants
    • Prolonged bleeding
  • Cyclosporin
    • Nephrotoxicity
  • Aminoglycosides
    • Nephrotoxicity
  • Corticosteroids
    • GI bleeding
  • Quinolones
    • Convulsions/seizures
  • Lithium
    • Decreased elimination, more toxicity
  • Digoxin
    • Decreased elimination, more toxicity
  • Diuretics
    • Decreased sodium excretion
  • Methotrexate
    • Increased toxicity
  • Antihypertensives
    • Decreased control of blood pressure

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with tiaprofenic acid?

The absorption rate is slightly decreased with food, however, taking it with a meal prevents gastrointestinal distress. This drug should not be taken with alcohol as it may increase the risk of gastrointestinal ulceration, bleeding, and hepatotoxicity.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with tiaprofenic acid?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Active bronchial asthma
  • Uncontrolled hypertension
  • Congestive heart failure (CHF)
  • Other cardiovascular diseases
  • Gastrointestinal diseases
    • Peptic ulcer disease (PUD)
    • Gastroesophageal reflux disease (GERD)
  • Conditions that require surgery
  • Urinary tract disorders
  • Prostatic disease
  • Elderly patients over the age of 60

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using tiaprofenic acid.

What is the dose of tiaprofenic acid for an adult?

  • Oral: take 600 mg/day in 2 to 3 divided doses; if using a modified-release preparation, only take it once a day.
  • Dose adjustments:
    • Elderly: initiate with the lowest dose.
    • Renal/hepatic impairment: reduce the dose to 200 mg twice a day. Avoid in severe impairment.

What is the dose of tiaprofenic acid for a child?

This drug is not recommended for use in children and the recommended dose has not been established. Consult with a doctor or pharmacist for alternatives and more information.

How is tiaprofenic acid available?

This drug is available in the following dosage forms and strengths:

  • Oral tablet 200 mg, 300 mg
  • Oral capsule, extended-release 200 mg, 300 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room. Management is symptomatic treatment. Convulsions should be treated with IV diazepam.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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