Gonadorelin

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Update Date 14/08/2020 . 5 mins read
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Uses

What is gonadorelin used for?

Gonadorelin is commonly used by women who are missing menstrual periods due to low levels of gonadotropin-releasing hormone (GnRH). It may be used as part of female infertility treatment.

This medication provides a synthetic version of GnRH which is responsible for the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

How should I take gonadorelin?

Gonadorelin is injected into a vein or under the skin using an infusion pump, as directed by your doctor. If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the medication package. Follow all instructions for using the infusion pump. Do not mix this medication until you are ready to use it. Before using this medication, check the solution visually for particles or discoloration. If either is present, do not use the solution.

Before each dose, clean the injection site with rubbing alcohol. If you are injecting the medication under the skin, change the injection site as directed by your doctor to lessen injury under the skin. If you are injecting the medication into a vein, you do not need to change the injection site unless directed by your doctor.

The dosage is based on your medical condition and response to treatment. Keep all medical appointments so your doctor can closely monitor your response and adjust your dosage if necessary. Do not change the dose unless directed by your doctor, and do not use this medication for a longer period than prescribed.

Learn how to store and discard medical supplies safely.

Tell your doctor if your condition does not improve.

How do I store gonadorelin?

Most of the time, this medicine will be given in a hospital or doctor’s office. If you store the medication at home, follow the packaging instructions, and keep it out of reach from children and pets.

Precautions & warnings

What should I know before using Gonadorelin?

Before using gonadorelin, inform your doctor or pharmacist if you have a history of allergies to this product or other substances. This product may contain several ingredients, both active and inactive; do not take this medication if you are allergic to any of the ingredients. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: ovarian cysts, kidney disease, tumors of the pituitary gland (such as prolactinoma), cancer of the reproductive organs (such as ovary, breast, uterus).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Use of gonadorelin may cause multiple births (such as twins, triplets). Discuss the risks and benefits of having such a pregnancy with your doctor.

This medication may be used during the first trimester of pregnancy as directed by your doctor. Tell your doctor right away if you become pregnant or think you may be pregnant. Consult your doctor for more details.

It is unknown if gonadorelin passes into breast milk. This medication is usually not used by nursing women. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this gonadorelin during pregnancy or while breastfeeding. Because FSH and LH are not the primary hormones of concern during pregnancy, this drug should not be administered to pregnant or lactating women. Please always consult with your doctor to weigh the potential benefits and risks before taking gonadorelin.

Gonadorelin is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from gonadorelin?

Headache, nausea, and mild abdominal pain may occur with menstrual bleeding. Injection site reactions (such as mild irritation, redness, bruising) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, agitation), signs of infection (such as fever, chills, persistent redness/pain/swelling/warmth at the injection site).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with gonadorelin?

Some products that may interact with this drug include other medications that cause ovulation.

Gonadorelin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with gonadorelin?

Gonadorelin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with gonadorelin?

Gonadorelin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this gonadorelin.

What is the dose of gonadorelin for an adult?

For diagnosis of hypothalamic-pituitary-gonadal dysfunction

Administer 100 mcg via IV or SQ injection. It should be given in the early follicular stage of the menstrual cycle (day 1-7).

For primary hypothalamic amenorrhea

Administer using intermittent pulse pump via IV or SQ injection, providing 5-20 mcg over 1 minute. Repeat every 90 minutes for up to 6 months or until conception occurs.

What is the dose of gonadorelin for a child?

For diagnosis of hypothalamic-pituitary-gonadal dysfunction

Children >1 year: 2.5 mcg/kg as a single dose. Maximum of 100 mcg per dose.

How is gonadorelin available?

Gonadorelin is available in the following dosage forms:

  • Solution for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of gonadorelin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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