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Update Date 08/05/2020 . 7 mins read
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What is Flixotide® (Fluticasone propionate) used for?

Flixotide® is commonly used for reducing swelling and irritation in the lungs. Also, it helps to prevent asthma attacks in people who need regular treatment. This is why they are sometimes called preventers. They need to be used regularly to see the effectiveness.

How should I take Flixotide® (Fluticasone propionate)?

You can use Flixotide® at any time of day, with or without food.

Using Flixotide® evohaler

  • It is important to start to breathe as slowly as possible just before using your evohaler.
  • Stand or sit upright when using your inhaler.
  • Remove the mouthpiece cover. Check inside and outside to make sure that the mouthpiece is clean and free of objects.
  • Shake the evohaler 4 or 5 times to ensure that any loose objects are removed and that the contents of the evohaler are evenly mixed.
  • Hold the evohaler upright with your thumb on the base, below the mouthpiece. Breathe out as far as is comfortable. Do not breathe in again yet.
  • Place the mouthpiece in your mouth between your teeth. Close your lips around it. Do not bite.
  • Breathe in through your mouth. Just after starting to breathe in, press down on the top of the canister to release a puff of medicine. Do this while still breathing in steadily and deeply.
  • Hold your breath; take the evohaler from your mouth and your finger from the top of the evohaler. Continue holding your breath for a few seconds, or as long as is comfortable.
  • If your doctor has told you to take two puffs, wait about half a minute before you take another puff by repeating steps 3 to 7.
  • Afterwards, rinse your mouth with water and spit it out.
  • After use always replace the mouthpiece cover straight away to keep out dust. Replace the cover by firmly pushing and clicking into position.

Using Flixotide® accuhaler

  • Inside the carton, your accuhaler is provided in a sealed foil wrapper. To open this wrapper, tear along the jagged edge, then remove the accuhaler, and throw the wrapper away. If you have trouble tearing the foil, do not use scissors or any other sharp objects as you may harm yourself or the accuhaler. Ask someone to help you. To open your accuhaler, hold the outer case in one hand and put the thumb of your other hand on the thumb grip. Push your thumb away from you as far as it will go. You will hear a click. This will open a small hole in the mouthpiece.
  • Hold your accuhaler with the mouthpiece towards you. You can hold it in either your right or left hand. Slide the lever away from you as far as it will go. You will hear a click. This places a dose of your medicine in the mouthpiece. Every time the lever is pulled back a blister is opened inside and the powder is ready for you to inhale. Do not play with the lever as this opens the blisters and wastes medicine.
  • Hold the accuhaler away from your mouth, breathe out as far as is comfortable. Do not breathe into your accuhaler. Do not breathe in again yet.
  • Put the mouthpiece to your lips; breathe in steadily and deeply through the accuhaler with your mouth, not through your nose. Remove the accuhaler from your mouth. Hold your breath for about 10 seconds or for as long as is comfortable. Breathe out slowly.
  • To close the accuhaler, slide the thumb grip back towards you, as far as it will go. You will hear a click. The lever will return to its original position and is reset. Your accuhaler is now ready for you to use again. Afterwards, rinse your mouth with water and spit it out.

Using your nebules:

  • The nebules are in a foil pack. Do not open the pack until you need to use them.
  • Hold the top of the nebule you have just removed. Twist the body to open it.
  • Put the open of the nebule into the nebuliser bowl and squeeze slowly to empty the content.
  • Assemble the nebuliser and use it as directed.
  • Repeat steps 2 to 4 to make up the dose needed if necessary.

Ask your health care provider any questions you may have about how to use each form of medication.

How do I store Flixotide® (Fluticasone propionate)?

Flixotide® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Flixotide® in the bathroom or the freezer. There may be different brands of Flixotide® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Flixotide® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Flixotide® (Fluticasone propionate)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Flixotide® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have ever been treated for tuberculosis.
  • You cannot tolerate or digest some sugars (have an intolerance to some sugars), talk to your doctor before using this medicine.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Flixotide® (Fluticasone propionate)?

Flixotide® may cause these side effects, such as:

  • Signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
  • Severe or ongoing nosebleeds;
  • Noisy breathing, runny nose, or crusting around your nostrils;
  • Redness, sores, or white patches in your mouth or throat;
  • Fever, chills, weakness, nausea, vomiting, flu symptoms;
  • Any wound that will not heal;
  • Blurred vision, eye pain, or seeing halos around lights.

Less serious side effects may include:

  • Headache, back pain;
  • Minor nosebleed;
  • Menstrual problems, loss of interest in sex;
  • Sinus pain, cough, sore throat;
  • Sores or white patches inside or around your nose.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Flixotide® (Fluticasone propionate)?

Flixotide® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, especially:

  • Steroid tablets;
  • Antiviral medicine (protease inhibitor);
  • Medicines used to treat fungal infections.

Does food or alcohol interact with Flixotide® (Fluticasone propionate)?

Flixotide® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Flixotide® (Fluticasone propionate)?

Flixotide® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, including tuberculosis.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Flixotide® (Fluticasone propionate) for an adult?

Flixotide® evohaler/Flixotide® accuhaler:

  • Mild asthma: the initial dose is 100 micrograms twice a day.
  • Moderate to severe asthma:
    • The initial dose is 250 to 500 micrograms twice a day.
    • The most taken should be 1000 micrograms twice a day.

Flixotide® nebules:

Adults and children over 16 years of age:

  • The initial dose is 0.5 to 2.0 mg (500 to 2000 micrograms) twice a day.
  • Flixotide® 0.5mg/2ml nebules provide you with a dose of 500 micrograms.
  • Flixotide® 2mg/2ml nebules provide you with a dose of 2000 micrograms.

What is the dose of Flixotide® (Fluticasone propionate) for a child?

Flixotide® accuhaler:

Children (4 to 16 years of age):

  • The initial dose is 50 micrograms twice a day.
  • The most taken should be 200 micrograms twice a day.
  • It is recommended that children being treated with steroids, including Flixotide® accuhaler have their height checked regularly by their doctor.

Flixotide® evohaler 125 and 250 micrograms: they are not recommended for children below 16 years of age.

How is Flixotide® (Fluticasone propionate) available?

Flixotide® is available in the following dosage forms and strengths:

  • Flixotide® accuhaler: 50, 100, 250, 500 microgram Fluticasone Propionate.
  • Flixotide® 0.5mg/2ml, 2mg/2ml nebules.
  • Flixotide® evohaler: 125, 250 microgram Fluticasone Propionate.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Flixotide®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Flixotide. https://www.drugs.com/uk/flixotide-125-evohaler-leaflet.html. Accessed October 6, 2016.

Flixotide. https://www.drugs.com/uk/flixotide-250-micrograms-accuhaler-leaflet.html. Accessed October 6, 2016.

Flixotide. https://www.drugs.com/uk/flixotide-2mg-2ml-nebules-leaflet.html. Accessed October 6, 2016.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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