Fenofibrate

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Update Date 14/08/2020 . 5 mins read
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Uses

What is fenofibrate used for?

Fenofibrate is part of a class of drugs known as antihyperlipidemics, specifically a fibrate. Together with a low-fat, low-cholesterol diet, fibrates help to lower total cholesterol and low-density lipoprotein (LDL) or “bad” cholesterol levels while improving high-density lipoprotein (HDL) or “good” cholesterol levels. This results in lowering the risk or formation of atherosclerotic plaques, which can cause hypertension and embolisms.

Fenofibrate is mainly indicated to treat the following conditions:

  • Hypertriglyceridemia
  • Mixed hyperlipidemia
  • Primary biliary cholangitis (off-label use)

How should I take fenofibrate?

Fenofibrate is available as oral tablets and capsules. The oral tablet should be taken by mouth without chewing or crushing it. The tablets must be taken with meals.

How do I store fenofibrate?

This drug should be stored at room temperature (15-30°C) and be protected from light and moisture. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using fenofibrate?

Lipid-lowering agents, including fenofibrate, may be associated with an increased risk of muscle pain, weakness, and fatigue. This risk is further increased in patients taking other medications such as statins or certain antibiotics.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to fenofibrate or other lipid-lowering agents.
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other lipid-lowering agents.
  • You have underlying health conditions.
  • You are pregnant or breastfeeding.

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category C drug. There is insufficient evidence from human studies that shows it can cause fetal harm when taken during pregnancy. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using fenofibrate?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea, vomiting, diarrhea
  • Fatigue
  • Myopathy
  • Muscle cramps
  • Headache
  • Dizziness
  • Rash
  • Photosensitivity
  • Hair loss
  • Sinusitis, rhinitis
  • Agranulocytosis, thrombocytopenia

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Gallstones
  • Pancreatitis
  • Hypersensitivity reaction
  • Rhabdomyolysis
  • Venous thromboembolism

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with fenofibrate?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with fenofibrate include:

  • Colchicine, statins, and other fibrates
    • Increased risk for myopathy and rhabdomyolysis
  • Ciclosporin
    • Increased risk of nephrotoxicity
  • Oral anticoagulants
    • Increased risk of bleeding
  • Ezetimibe
    • May enhance the adverse effects of this drug
  • Bile acid sequestrants
    • May decrease the absorption of these drugs

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with fenofibrate?

This medication should be taken with meals for optimal absorption and effect. This drug should not be taken with alcohol as it may increase the risk of liver damage.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with fenofibrate?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Severe renal impairment
  • Active liver disease
  • Gallbladder disease
  • Pancreatitis

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using fenofibrate.

What is the dose of fenofibrate for an adult?

For severe hypertriglyceridemia

  • Standard micronized formulation
    • Initial dose: take 67 mg three times a day or 200 mg once per day.
    • Maintenance dose: may be reduced to 67 mg two times per day or increased to 67 mg four times per day, or 267 mg once daily, depending on your response.
  • Non-micronized formulation
    • Initial dose: 200-300 mg per day, given in divided doses.
    • Maintenance dose: take 200-400 mg per day depending on your response.
  • Improved bioavailability formulation: take 40-160 mg per day.

For mixed hyperlipidemia

  • Standard micronized formulation
    • Initial dose: take 67 mg three times a day or 200 mg once per day.
    • Maintenance dose: may be reduced to 67 mg two times per day or increased to 67 mg four times per day, or 267 mg once daily, depending on your response.
  • Non-micronized formulation
    • Initial dose: 200-300 mg per day, given in divided doses.
    • Maintenance dose: take 200-400 mg per day depending on your response.
  • Improved bioavailability formulation: take 40-160 mg per day.

What is the dose of fenofibrate for a child?

The recommended dosage and use of this drug in children have not been established. Consult with your doctor or pharmacist for alternatives or more information.

How is fenofibrate available?

This drug is available in the following brands, dosage forms, and strengths:

  • Audra capsule 300 mg
  • Diafeno capsule 200 mg
  • Fenofast capsule 200 mg
  • Fenogal capsule 160 mg
  • Fenolit capsule 200 mg
  • Lipanthyl NT tablet 145 mg
  • Lipanthyl Supra modified-release tablet 160 mg
  • Lipanthyl 67M capsule 67 mg
  • Lipiduce film-coated tablet 160 mg
  • Lipway tablet 160 mg
  • Lipway SR modified-release capsule 250 mg
  • Nubrex capsule 300 mg
  • Trichek capsule 200 mg
  • Trolip capsule 300 mg
  • Zinof capsule 200 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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