Lifestyle and inheritance from family
It can be difficult to separate lifestyle risk from genetic risk. Lifestyle choices tend to be influenced by family. If parents are sedentary, often their children are also sedentary. Parents with unhealthy eating habits can also influence the next generation.
Is diabetes hereditary? Which gene is involved in type 2 diabetes?
Studies by the American Diabetes Association in twins suggest that type 2 diabetes can be influenced by genetics. However, these studies are complicated by effects of the environment as it also has an impact on the risk of type 2 diabetes.
Scientists are still doing research. To date, many mutations have been shown to affect the risk of type 2 diabetes. In general, the contribution of one gene is negligible, but each mutation increases the risk of the disease.
In general, mutations in any of the inherited genes involved in glucose regulation have a significant effect on the risk of type 2 diabetes.
These include genes that control:
- Glucose production
- The production of insulin
- The body’s sensitivity to glucose levels
- Regulation of insulin levels
Genes associated with type 2 diabetes risk include:
- TCF7L2, a gene that affects insulin secretion and glucose production.
- Urea sulfonylurea receptor (ABCC8), which helps to regulate insulin.
- Calpain 10, associated with risk of type 2 diabetes in Mexican-Americans.
- Glucose transporter gene 2 (GLUT2), which helps glucose move into the pancreas
- The glucagon receptor (GCGR), the hormone glucagon is involved in glucose regulation.
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