The Papanicolau (Pap) test would normally only be done on women to determine cervical cancer. rather than men, however; it has been found to also work to some extent for men who have immunodeficiencies or are at higher risk to get cancer and other diseases and infections. This test is actually normally conducted to look for cervical cancer, but because of the method they use to find cancer, it is equally effective as an HPV test, and even though not normally done on men, it works mostly the same way.
The doctor will get a sample of cells from the urethra instead of the cervix of the woman, and it is these cells that will be sent to the lab and examined. They will stain these sample cells with immunoperoxidase. This allows doctors to locate the Human Papillomavirus that are damaging those very cells.
Anal cytology
This is another kind of Papinocolau test. Very much like the urethral or cervical variants of this test, this requires first getting sample cells from the anal cavity, usually 2-3 inches from the anal opening, using a swab moistened with tap water.
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