That same study highlighted the potential protective effect of estrogen against COVID-19. It recommended future clinical trials and prospective studies to confirm this protective effect.
Another study published in September 2021 wanted to investigate the connection of COVID-19 positivity and severity with estrogen exposure. That study’s findings supported a protective effect of estrogen exposure on COVID-19. It was based on a positive association between predicted COVID-19 with menopausal status and a negative association with the use of a combined oral contraceptive pill.
High estrogen levels lead to lower COVID deaths
The recent Swedish study noted that 17% of the women were taking estrogen supplements to relieve menopausal symptoms. The women who gained extra estrogen had a 53% lower risk of dying from COVID-19 compared to untreated women after adjusting for other risk factors.
This was an observational study that cannot prove higher estrogen levels are protective. Dr. Malin Sund of Umea University said in a Reuters article that the women were infected before vaccines were available.
“Vaccination has clearly been shown to protect from COVID-19 related mortality and the potential added value from estrogen (in vaccinated women) cannot be estimated from this data,” Sund said in the same story.
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